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Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review
This narrative review aims to summarize all the latest studies published between 2015-2021 concerning the management protocols adopted for poor ovarian response (POR) cases. Patients defined as “poor responders” show minimal response to controlled ovarian hyperstimulation, although there is no stand...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Academy of Sciences and Arts of Bosnia and Herzegovina
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982854/ https://www.ncbi.nlm.nih.gov/pubmed/36318003 http://dx.doi.org/10.5644/ama2006-124.379 |
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author | Galatis, Dionysios Kalopita, Konstantina Grypiotis, Ioannis Flessas, Ioannis Kiriakopoulos, Nikolaos Micha, Georgia |
author_facet | Galatis, Dionysios Kalopita, Konstantina Grypiotis, Ioannis Flessas, Ioannis Kiriakopoulos, Nikolaos Micha, Georgia |
author_sort | Galatis, Dionysios |
collection | PubMed |
description | This narrative review aims to summarize all the latest studies published between 2015-2021 concerning the management protocols adopted for poor ovarian response (POR) cases. Patients defined as “poor responders” show minimal response to controlled ovarian hyperstimulation, although there is no standard definition for POR. Although infertility specialists are endeavoring to improve cycle outcomes in poor responders by adopting multiple management strategies, still the estimated risk of cycle cancellation is about 20%. All the studies performed during this study period were evaluated and their results were recorded. The latest published protocols to improve oocyte retrieval in poor responders include anti-Mϋllerian hormone, clomiphene citrate, co-enzyme Q(10,) corifollitropin, dehydroepiandrosterone, double stimulation, Follicle Stimulation Hormone, Growth Hormone, Gonadotropin-releasing hormone agonists, letrozole, human chorionic gonadotropin, Luteinizing Hormone, progesterone and testosterone. CONCLUSION. Although many strategies have been suggested to manage POR, none has been proven superior to the others. Further large-scale randomized studies are needed to validate experimental techniques leading towards successful individualized treatment regimens. |
format | Online Article Text |
id | pubmed-9982854 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Academy of Sciences and Arts of Bosnia and Herzegovina |
record_format | MEDLINE/PubMed |
spelling | pubmed-99828542023-03-14 Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review Galatis, Dionysios Kalopita, Konstantina Grypiotis, Ioannis Flessas, Ioannis Kiriakopoulos, Nikolaos Micha, Georgia Acta Med Acad Narrative Review This narrative review aims to summarize all the latest studies published between 2015-2021 concerning the management protocols adopted for poor ovarian response (POR) cases. Patients defined as “poor responders” show minimal response to controlled ovarian hyperstimulation, although there is no standard definition for POR. Although infertility specialists are endeavoring to improve cycle outcomes in poor responders by adopting multiple management strategies, still the estimated risk of cycle cancellation is about 20%. All the studies performed during this study period were evaluated and their results were recorded. The latest published protocols to improve oocyte retrieval in poor responders include anti-Mϋllerian hormone, clomiphene citrate, co-enzyme Q(10,) corifollitropin, dehydroepiandrosterone, double stimulation, Follicle Stimulation Hormone, Growth Hormone, Gonadotropin-releasing hormone agonists, letrozole, human chorionic gonadotropin, Luteinizing Hormone, progesterone and testosterone. CONCLUSION. Although many strategies have been suggested to manage POR, none has been proven superior to the others. Further large-scale randomized studies are needed to validate experimental techniques leading towards successful individualized treatment regimens. Academy of Sciences and Arts of Bosnia and Herzegovina 2022 /pmc/articles/PMC9982854/ /pubmed/36318003 http://dx.doi.org/10.5644/ama2006-124.379 Text en Copyright © 2022 Academy of Sciences and Arts of Bosnia and Herzegovina https://creativecommons.org/licenses/by-nc/3.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Narrative Review Galatis, Dionysios Kalopita, Konstantina Grypiotis, Ioannis Flessas, Ioannis Kiriakopoulos, Nikolaos Micha, Georgia Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review |
title | Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review |
title_full | Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review |
title_fullStr | Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review |
title_full_unstemmed | Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review |
title_short | Researching the Phenomenon of Poor Ovarian Responders and Management Strategies in IVF: A Narrative Review |
title_sort | researching the phenomenon of poor ovarian responders and management strategies in ivf: a narrative review |
topic | Narrative Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9982854/ https://www.ncbi.nlm.nih.gov/pubmed/36318003 http://dx.doi.org/10.5644/ama2006-124.379 |
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