Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model

[Image: see text] Many cases of accidental death associated with drug overdose are due to chronic opioid use, tolerance, and addiction. Analgesic tolerance is characterized by a decreased response to the analgesic effects of opioids, requiring increasingly higher doses to maintain the desired level...

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Detalles Bibliográficos
Autores principales: Harris, Lynnea D., Regan, Michael C., Myers, Scott J., Nocilla, Kelsey A., Akins, Nicholas S., Tahirovic, Yesim A., Wilson, Lawrence J., Dingledine, Ray, Furukawa, Hiro, Traynelis, Stephen F., Liotta, Dennis C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983021/
https://www.ncbi.nlm.nih.gov/pubmed/36779874
http://dx.doi.org/10.1021/acschemneuro.2c00779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983021/
https://www.ncbi.nlm.nih.gov/pubmed/36779874
http://dx.doi.org/10.1021/acschemneuro.2c00779

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