Cargando…

Novel GluN2B-Selective NMDA Receptor Negative Allosteric Modulator Possesses Intrinsic Analgesic Properties and Enhances Analgesia of Morphine in a Rodent Tail Flick Pain Model

[Image: see text] Many cases of accidental death associated with drug overdose are due to chronic opioid use, tolerance, and addiction. Analgesic tolerance is characterized by a decreased response to the analgesic effects of opioids, requiring increasingly higher doses to maintain the desired level...

Descripción completa

Detalles Bibliográficos
Autores principales:	Harris, Lynnea D., Regan, Michael C., Myers, Scott J., Nocilla, Kelsey A., Akins, Nicholas S., Tahirovic, Yesim A., Wilson, Lawrence J., Dingledine, Ray, Furukawa, Hiro, Traynelis, Stephen F., Liotta, Dennis C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2023
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983021/ https://www.ncbi.nlm.nih.gov/pubmed/36779874 http://dx.doi.org/10.1021/acschemneuro.2c00779

Ejemplares similares

Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors
por: Karakas, Erkan, et al.
Publicado: (2011)

Allosteric modulation of GluN1/GluN3 NMDA receptors by GluN1-selective competitive antagonists
por: Rouzbeh, Nirvan, et al.
Publicado: (2023)

GluN2A and GluN2B NMDA receptors use distinct allosteric routes
por: Tian, Meilin, et al.
Publicado: (2021)

Identification of a Subtype-Selective Allosteric Inhibitor of GluN1/GluN3 NMDA Receptors
por: Zeng, Yue, et al.
Publicado: (2022)

Structural elements of a pH-sensitive inhibitor binding site in NMDA receptors
por: Regan, Michael C., et al.
Publicado: (2019)

Unmasking GluN1/GluN3A excitatory glycine NMDA receptors
por: Grand, Teddy, et al.
Publicado: (2018)

Development of a Dihydroquinoline–Pyrazoline GluN2C/2D-Selective Negative Allosteric Modulator of the N-Methyl-d-aspartate Receptor
por: D’Erasmo, Michael P., et al.
Publicado: (2023)

GluN2A and GluN2B subunit-containing NMDA receptors in hippocampal plasticity
por: Shipton, Olivia A., et al.
Publicado: (2014)

Targeted NMDA Receptor Interventions for Autism: Developmentally Determined Expression of GluN2B and GluN2A-Containing Receptors and Balanced Allosteric Modulatory Approaches
por: Deutsch, Stephen I., et al.
Publicado: (2022)

Structure, function, and allosteric modulation of NMDA receptors
por: Hansen, Kasper B., et al.
Publicado: (2018)

A single-channel mechanism for pharmacological potentiation of GluN1/GluN2A NMDA receptors
por: Chopra, Divyan A., et al.
Publicado: (2017)

Unique Biology and Single-Channel Properties of GluN2A- and GluN2C-Containing Triheteromeric N-Methyl-D-Aspartate Receptors
por: Bhattacharya , Subhrajit, et al.
Publicado: (2018)

Local constraints in either the GluN1 or GluN2 subunit equally impair NMDA receptor pore opening
por: Talukder, Iehab, et al.
Publicado: (2011)

GluN1 and GluN2A NMDA Receptor Subunits Increase in the Hippocampus during Memory Consolidation in the Rat
por: Cercato, Magali C., et al.
Publicado: (2017)

GluN2A‐Selective NMDA Receptor Antagonists: Mimicking the U‐Shaped Bioactive Conformation of TCN‐201 by a [2.2]Paracyclophane System
por: Steigerwald, Ruben, et al.
Publicado: (2022)

Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
por: Wang, Jue Xiang, et al.
Publicado: (2020)

Influence of GluN2 subunit identity on NMDA receptor function
por: Wyllie, D.J.A., et al.
Publicado: (2013)

Effects of morphine and NeuroAid on the expression levels of GluN2A and GluN3A in the hippocampus and striatum of rats
por: Heshmatzad, Katayoun, et al.
Publicado: (2021)

Lupus autoantibodies act as positive allosteric modulators at GluN2A-containing NMDA receptors and impair spatial memory
por: Chan, Kelvin, et al.
Publicado: (2020)

Endocytosis of GluN2B-containing NMDA receptor mediates NMDA-induced excitotoxicity
por: Wu, Yu, et al.
Publicado: (2017)

Open-channel blockade is less effective on GluN3B than GluN3A subunit-containing NMDA receptors
por: McClymont, David W., et al.
Publicado: (2012)

The Nucleosome Assembly Protein TSPYL2 Regulates the Expression of NMDA Receptor Subunits GluN2A and GluN2B
por: Tsang, Ka Hing, et al.
Publicado: (2014)

Structural features in the glycine-binding sites of the GluN1 and GluN3A subunits regulate the surface delivery of NMDA receptors
por: Skrenkova, Kristyna, et al.
Publicado: (2019)

The Developmental Shift of NMDA Receptor Composition Proceeds Independently of GluN2 Subunit-Specific GluN2 C-Terminal Sequences
por: McKay, Sean, et al.
Publicado: (2018)

d-Serine agonism of GluN1-GluN3 NMDA receptors regulates the activity of enteric neurons and coordinates gut motility
por: Osorio, Nancy, et al.
Publicado: (2023)

Mg(2+) block properties of triheteromeric GluN1–GluN2B–GluN2D NMDA receptors on neonatal rat substantia nigra pars compacta dopaminergic neurones
por: Huang, Zhuo, et al.
Publicado: (2014)

GluN3A: An NMDA Receptor Subunit with Exquisite Properties and Functions
por: Kehoe, Laura A., et al.
Publicado: (2013)

Astrocytes increase the activity of synaptic GluN2B NMDA receptors
por: Hahn, Junghyun, et al.
Publicado: (2015)

Potential Roles for the GluN2D NMDA Receptor Subunit in Schizophrenia
por: Vinnakota, Chitra, et al.
Publicado: (2023)

Age-Dependent, Subunit Specific Action of Hydrogen Sulfide on GluN1/2A and GluN1/2B NMDA Receptors
por: Yakovlev, Aleksey V., et al.
Publicado: (2017)

The NMDA Receptor Subunit (GluN1 and GluN2A) Modulation Following Different Conditions of Cocaine Abstinence in Rat Brain Structures
por: Smaga, Irena, et al.
Publicado: (2021)

Palmitoylation at Two Cysteine Clusters on the C-Terminus of GluN2A and GluN2B Differentially Control Synaptic Targeting of NMDA Receptors
por: Mattison, Hayley A., et al.
Publicado: (2012)

The role of GluN2A and GluN2B NMDA receptor subunits in AgRP and POMC neurons on body weight and glucose homeostasis
por: Üner, Aykut, et al.
Publicado: (2015)

Differential effect of NMDA receptor GluN2C and GluN2D subunit ablation on behavior and channel blocker-induced schizophrenia phenotypes
por: Shelkar, Gajanan P., et al.
Publicado: (2019)

GluN2 Subunit-Dependent Redox Modulation of NMDA Receptor Activation by Homocysteine
por: Sibarov, Dmitry A., et al.
Publicado: (2020)

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients
por: Mellone, Manuela, et al.
Publicado: (2015)

Design, Synthesis, and Structure–Activity Relationship of a Novel Series of GluN2C-Selective Potentiators
por: Zimmerman, Sommer S., et al.
Publicado: (2014)

An Alternating GluN1-2-1-2 Subunit Arrangement in Mature NMDA Receptors
por: Riou, Morgane, et al.
Publicado: (2012)

GluN2A Subunit-Containing NMDA Receptors Are the Preferential Neuronal Targets of Homocysteine
por: Sibarov, Dmitry A., et al.
Publicado: (2016)

Functional assessment of the NMDA receptor variant GluN2A (R586K)
por: Marwick, Katie F.M., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_7ofct194nfe5dvi9lcg1s6p6t1