Cargando…

U0126 and BAY11-7082 Inhibit the Progression of Endometriosis in a Rat Model by Suppressing the MEK/ERK/NF-κB Pathway

Endometriosis is an aggressive disease. It is the main cause of chronic pelvic pain, dysmenorrhea, and infertility, affecting the well-being of women. This study aimed to explore the role of U0126 and BAY11-7082 in endometriosis (EMs) treatment in rats by targeting the MEK/ERK/NF-κB pathway. The EMs...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wang, Fang, Li, Yong Mei, Li, Ru Yue, Yang, Yu E., Wei, Meng, Ha, Chunfang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Mary Ann Liebert, Inc., publishers 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983136/ https://www.ncbi.nlm.nih.gov/pubmed/36874235 http://dx.doi.org/10.1089/whr.2021.0151

Ejemplares similares

Effects of the NF-κB Signaling Pathway Inhibitor BAY11-7082 in the Replication of ASFV
por: Gao, Qi, et al.
Publicado: (2022)

Synergistic inhibition of lung cancer cells by EGCG and NF-κB inhibitor BAY11-7082
por: Zhang, Lingyu, et al.
Publicado: (2019)

MEK Inhibitor U0126 Reverses Protection of Axons from Wallerian Degeneration Independently of MEK–ERK Signaling
por: Evans, Catherine, et al.
Publicado: (2013)

In Vitro Efficacy of Ebselen and BAY 11-7082 Against Naegleria fowleri
por: Debnath, Anjan, et al.
Publicado: (2018)

Astrocytes Decreased the Sensitivity of Glioblastoma Cells to Temozolomide and Bay 11-7082
por: Pustchi, Sadaf E., et al.
Publicado: (2020)

The Pharmacological NF-κB Inhibitor BAY11-7082 Induces Cell Apoptosis and Inhibits the Migration of Human Uveal Melanoma Cells
por: Hu, Shuiqing, et al.
Publicado: (2012)

The IKK Inhibitor Bay 11-7082 Induces Cell Death Independent from Inhibition of Activation of NFκB Transcription Factors
por: Rauert-Wunderlich, Hilka, et al.
Publicado: (2013)

Potent block of potassium channels by MEK inhibitor U0126 in primary cultures and brain slices
por: Wang, Jin-Zhao, et al.
Publicado: (2018)

Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB
por: Huang, Wei-Chieh, et al.
Publicado: (2022)

The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish
por: Hawkins, Thomas A, et al.
Publicado: (2008)

U0126 Protects Cells against Oxidative Stress Independent of Its Function as a MEK Inhibitor
por: Ong, Qunxiang, et al.
Publicado: (2014)

The MEK inhibitor U0126 ameliorates diabetic cardiomyopathy by restricting XBP1's phosphorylation dependent SUMOylation
por: Wang, Tao, et al.
Publicado: (2021)

Nuclear factor-κB inhibitor Bay11-7082 inhibits gastric cancer cell proliferation by inhibiting Gli1 expression
por: Yan, Yan, et al.
Publicado: (2021)

BAY 11-7082 Is a Broad-Spectrum Inhibitor with Anti-Inflammatory Activity against Multiple Targets
por: Lee, Jaehwi, et al.
Publicado: (2012)

Nonwoven-based gelatin/polycaprolactone membrane loaded with ERK inhibitor U0126 for treatment of tendon defects
por: Hou, Yonghui, et al.
Publicado: (2022)

U0126 Compound Triggers Thermogenic Differentiation in Preadipocytes via ERK-AMPK Signaling Axis
por: Onikanni, Sunday Amos, et al.
Publicado: (2023)

The anti-inflammatory drug BAY 11-7082 suppresses the MyD88-dependent signalling network by targeting the ubiquitin system
por: Strickson, Sam, et al.
Publicado: (2013)

Pharmacological targeting of glucose-6-phosphate dehydrogenase in human erythrocytes by Bay 11–7082, parthenolide and dimethyl fumarate
por: Ghashghaeinia, Mehrdad, et al.
Publicado: (2016)

U0126: Not only a MAPK kinase inhibitor
por: You, Yijie, et al.
Publicado: (2022)

MEK1/2 inhibitor U0126, but not nimodipine, reduces upregulation of cerebrovascular contractile receptors after subarachnoid haemorrhage in rats
por: Christensen, Simon T., et al.
Publicado: (2019)

Bay11-7082 inhibits the disintegration of the lymphendothelial barrier triggered by MCF-7 breast cancer spheroids; the role of ICAM-1 and adhesion
por: Viola, K, et al.
Publicado: (2013)

The ERK(1/2) Inhibitor U0126 Attenuates Diabetes-Induced Upregulation of MMP-9 and Biomarkers of Inflammation in the Retina
por: Mohammad, Ghulam, et al.
Publicado: (2013)

Inhibitor of IκB kinase activity, BAY 11-7082, interferes with interferon regulatory factor 7 nuclear translocation and type I interferon production by plasmacytoid dendritic cells
por: Miyamoto, Rie, et al.
Publicado: (2010)

In Vivo Short-Term Topical Application of BAY 11-7082 Prevents the Acidic Bile–Induced mRNA and miRNA Oncogenic Phenotypes in Exposed Murine Hypopharyngeal Mucosa()()
por: Sasaki, Clarence T., et al.
Publicado: (2018)

SERPINA11 Inhibits Metastasis in Hepatocellular Carcinoma by Suppressing MEK/ERK Signaling Pathway
por: Song, Ye, et al.
Publicado: (2021)

PA01.26. Clinical application of quantum physics in ayurveda
por: Gandhi, Manaan, et al.
Publicado: (2012)

Aberrant MEK5/ERK5 signalling contributes to human colon cancer progression via NF-κB activation
por: Simões, A E S, et al.
Publicado: (2015)

Synergistic effects of a cremophor EL drug delivery system and its U0126 cargo in an ex vivo model
por: Christensen, S. T., et al.
Publicado: (2019)

Inhibition of NF-κB activation by BAY 11-7821 suppresses the proliferation and inflammation of glioma cells through inducing autophagy
por: Xie, Kui, et al.
Publicado: (2022)

Visfatin upregulates VEGF-C expression and lymphangiogenesis in esophageal cancer by activating MEK1/2-ERK and NF-κB signaling
por: Huang, Chang-Lun, et al.
Publicado: (2023)

Effects of U0126 and MK2206 on cell growth and re-growth of endometriotic stromal cells grown on substrates of varying stiffness
por: Matsuzaki, Sachiko, et al.
Publicado: (2017)

Upregulation of CFTR in patients with endometriosis and its involvement in NFκB-uPAR dependent cell migration
por: Huang, Wenqing, et al.
Publicado: (2017)

Overexpression of Tpl2 is linked to imatinib resistance and activation of MEK‐ERK and NF‐κB pathways in a model of chronic myeloid leukemia
por: Chorzalska, Anna, et al.
Publicado: (2018)

Sorafenib pretreatment enhances radiotherapy through targeting MEK/ERK/NF-κB pathway in human hepatocellular carcinoma-bearing mouse model
por: Chen, John Chun-Hao, et al.
Publicado: (2016)

S1P promotes IL-6 expression in osteoblasts through the PI3K, MEK/ERK and NF-κB signaling pathways
por: Hu, Sung-Lin, et al.
Publicado: (2020)

Combination treatment with U0126 and rt-PA prevents adverse effects of the delayed rt-PA treatment after acute ischemic stroke
por: Orset, Cyrille, et al.
Publicado: (2021)

Modulation of Osteogenic Differentiation of Adipose-Derived Stromal Cells by Co-Treatment with 3, 4’-Dihydroxyflavone, U0126, and N-Acetyl Cysteine
por: Song, Kwonwoo, et al.
Publicado: (2022)

Drug Signature-based Finding of Additional Clinical Use of LC28-0126 for Neutrophilic Bronchial Asthma
por: Shin, Eunji, et al.
Publicado: (2015)

Bay11-7082 attenuates neuropathic pain via inhibition of nuclear factor-kappa B and nucleotide-binding domain-like receptor protein 3 inflammasome activation in dorsal root ganglions in a rat model of lumbar disc herniation
por: Zhang, Ailiang, et al.
Publicado: (2017)

CDCA8 induced by NF-YA promotes hepatocellular carcinoma progression by regulating the MEK/ERK pathway
por: Chen, Erbao, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_jip4fshl9c535o27e4538e3kq5