Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia

BACKGROUND: Distinct oral atypical antipsychotics have different effects on autonomic nervous system (ANS) activity. Among them, oral aripiprazole has been linked to dysfunction of the ANS in schizophrenia. Long-acting injectable aripiprazole is a major treatment option for schizophrenia, but the ef...

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Autores principales: Hattori, Saki, Suda, Akira, Kishida, Ikuko, Miyauchi, Masatoshi, Shiraishi, Yohko, Noguchi, Nobuhiko, Furuno, Taku, Asami, Takeshi, Fujibayashi, Mami, Tsujita, Natsuki, Ishii, Chie, Ishii, Norio, Saeki, Takashi, Fukushima, Tadashi, Moritani, Toshio, Saigusa, Yusuke, Hishimoto, Akitoyo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983165/
https://www.ncbi.nlm.nih.gov/pubmed/36869320
http://dx.doi.org/10.1186/s12888-023-04617-y
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author Hattori, Saki
Suda, Akira
Kishida, Ikuko
Miyauchi, Masatoshi
Shiraishi, Yohko
Noguchi, Nobuhiko
Furuno, Taku
Asami, Takeshi
Fujibayashi, Mami
Tsujita, Natsuki
Ishii, Chie
Ishii, Norio
Saeki, Takashi
Fukushima, Tadashi
Moritani, Toshio
Saigusa, Yusuke
Hishimoto, Akitoyo
author_facet Hattori, Saki
Suda, Akira
Kishida, Ikuko
Miyauchi, Masatoshi
Shiraishi, Yohko
Noguchi, Nobuhiko
Furuno, Taku
Asami, Takeshi
Fujibayashi, Mami
Tsujita, Natsuki
Ishii, Chie
Ishii, Norio
Saeki, Takashi
Fukushima, Tadashi
Moritani, Toshio
Saigusa, Yusuke
Hishimoto, Akitoyo
author_sort Hattori, Saki
collection PubMed
description BACKGROUND: Distinct oral atypical antipsychotics have different effects on autonomic nervous system (ANS) activity. Among them, oral aripiprazole has been linked to dysfunction of the ANS in schizophrenia. Long-acting injectable aripiprazole is a major treatment option for schizophrenia, but the effect of the aripiprazole formulation on ANS activity remains unclear. In this study, we compared ANS activity between oral aripiprazole and aripiprazole once-monthly (AOM) in schizophrenia. METHODS: Of the 122 patients with schizophrenia who participated in this study, 72 received oral aripiprazole and 50 received AOM as monotherapy. We used power spectral analysis of heart rate variability to assess ANS activity. RESULTS: Patients who received oral aripiprazole showed significantly diminished sympathetic nervous activity compared with those who received AOM. Multiple regression analysis revealed that the aripiprazole formulation significantly influenced sympathetic nervous activity. CONCLUSION: Compared with oral aripiprazole, AOM appears to have fewer adverse effects, such as sympathetic nervous dysfunction.
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spelling pubmed-99831652023-03-04 Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia Hattori, Saki Suda, Akira Kishida, Ikuko Miyauchi, Masatoshi Shiraishi, Yohko Noguchi, Nobuhiko Furuno, Taku Asami, Takeshi Fujibayashi, Mami Tsujita, Natsuki Ishii, Chie Ishii, Norio Saeki, Takashi Fukushima, Tadashi Moritani, Toshio Saigusa, Yusuke Hishimoto, Akitoyo BMC Psychiatry Research BACKGROUND: Distinct oral atypical antipsychotics have different effects on autonomic nervous system (ANS) activity. Among them, oral aripiprazole has been linked to dysfunction of the ANS in schizophrenia. Long-acting injectable aripiprazole is a major treatment option for schizophrenia, but the effect of the aripiprazole formulation on ANS activity remains unclear. In this study, we compared ANS activity between oral aripiprazole and aripiprazole once-monthly (AOM) in schizophrenia. METHODS: Of the 122 patients with schizophrenia who participated in this study, 72 received oral aripiprazole and 50 received AOM as monotherapy. We used power spectral analysis of heart rate variability to assess ANS activity. RESULTS: Patients who received oral aripiprazole showed significantly diminished sympathetic nervous activity compared with those who received AOM. Multiple regression analysis revealed that the aripiprazole formulation significantly influenced sympathetic nervous activity. CONCLUSION: Compared with oral aripiprazole, AOM appears to have fewer adverse effects, such as sympathetic nervous dysfunction. BioMed Central 2023-03-03 /pmc/articles/PMC9983165/ /pubmed/36869320 http://dx.doi.org/10.1186/s12888-023-04617-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Hattori, Saki
Suda, Akira
Kishida, Ikuko
Miyauchi, Masatoshi
Shiraishi, Yohko
Noguchi, Nobuhiko
Furuno, Taku
Asami, Takeshi
Fujibayashi, Mami
Tsujita, Natsuki
Ishii, Chie
Ishii, Norio
Saeki, Takashi
Fukushima, Tadashi
Moritani, Toshio
Saigusa, Yusuke
Hishimoto, Akitoyo
Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia
title Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia
title_full Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia
title_fullStr Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia
title_full_unstemmed Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia
title_short Differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia
title_sort differences in autonomic nervous system activity between long-acting injectable aripiprazole and oral aripiprazole in schizophrenia
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983165/
https://www.ncbi.nlm.nih.gov/pubmed/36869320
http://dx.doi.org/10.1186/s12888-023-04617-y
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