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Subtype-specific kinase dependency regulates growth and metastasis of poor-prognosis mesenchymal colorectal cancer

BACKGROUND: Colorectal cancer (CRC) can be divided into four consensus molecular subtypes (CMS), each with distinct biological features. CMS4 is associated with epithelial-mesenchymal transition and stromal infiltration (Guinney et al., Nat Med 21:1350–6, 2015; Linnekamp et al., Cell Death Differ 25...

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Detalles Bibliográficos
Autores principales:	Buikhuisen, Joyce Y., Gomez Barila, Patricia M., Cameron, Kate, Suijkerbuijk, Saskia J. E., Lieftink, Cor, di Franco, Simone, Krotenberg Garcia, Ana, Uceda Castro, Rebeca, Lenos, Kristiaan J., Nijman, Lisanne E., Torang, Arezo, Longobardi, Ciro, de Jong, Joan H., Dekker, Daniëlle, Stassi, Giorgio, Vermeulen, Louis, Beijersbergen, Roderick L., van Rheenen, Jacco, Huveneers, Stephan, Medema, Jan Paul
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983221/ https://www.ncbi.nlm.nih.gov/pubmed/36869386 http://dx.doi.org/10.1186/s13046-023-02600-9

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