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Opposing effects of β-2 and β-1 adrenergic receptor signaling on neuroinflammation and dopaminergic neuron survival in α-synuclein-mediated neurotoxicity

BACKGROUND: Noradrenergic neurons in the locus coeruleus (LC) are the primary source of norepinephrine (NE) in the brain and degeneration of these neurons is reported in the early stages of Parkinson’s disease (PD), even prior to dopaminergic neuron degeneration in the substantia nigra (SN), which i...

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Detalles Bibliográficos
Autores principales:	Torrente, Daniel, Su, Enming J., Schielke, Gerald P., Warnock, Mark, Mann, Kris, Lawrence, Daniel A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983231/ https://www.ncbi.nlm.nih.gov/pubmed/36864439 http://dx.doi.org/10.1186/s12974-023-02748-3

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