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Validation of the THINC-It Tool for Assessment of Cognitive Impairment in Patients with Bipolar Depression

BACKGROUND: Cognitive impairment is one of the core features of bipolar depression. A unified, reliable, and valid assessment tool is key to screening and assessing cognitive impairment. The THINC-Integrated Tool (THINC-it) is a simple and quick battery for screening cognitive impairment in patients...

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Autores principales: Zhu, Na, Zhang, WeiHua, Huang, Jia, Su, Yousong, Lu, JingFang, Yang, Lu, Shi, YiFan, Hu, ShaoHua, Chen, Jun, Fang, Yiru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983437/
https://www.ncbi.nlm.nih.gov/pubmed/36874958
http://dx.doi.org/10.2147/NDT.S401095
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author Zhu, Na
Zhang, WeiHua
Huang, Jia
Su, Yousong
Lu, JingFang
Yang, Lu
Shi, YiFan
Hu, ShaoHua
Chen, Jun
Fang, Yiru
author_facet Zhu, Na
Zhang, WeiHua
Huang, Jia
Su, Yousong
Lu, JingFang
Yang, Lu
Shi, YiFan
Hu, ShaoHua
Chen, Jun
Fang, Yiru
author_sort Zhu, Na
collection PubMed
description BACKGROUND: Cognitive impairment is one of the core features of bipolar depression. A unified, reliable, and valid assessment tool is key to screening and assessing cognitive impairment. The THINC-Integrated Tool (THINC-it) is a simple and quick battery for screening cognitive impairment in patients with major depressive disorder. However, the use of the tool has not been validated in patients with bipolar depression. METHODS: The cognitive functions of 120 patients with bipolar depression and 100 healthy controls were evaluated using the THINC-it tool including Spotter, Symbol Check, Codebreaker, Trials, and the only one subjective test (PDQ-5-D) and five corresponding standard tests. A psychometric analysis of the THINC-it tool was performed. RESULTS: The overall Cronbach’s alpha coefficient of the THINC-it tool was 0.815. The intra-group correlation coefficient (ICC) of retest reliability ranged from 0.571 to 0.854 (P<0.001), while the correlation r of parallel validity ranged from 0.291 to 0.921 (P<0.001). There were significant differences in the two groups Z-scores of THINC-it total score, Spotter, Codebreaker, Trails, and PDQ-5-D (P<0.05). Construct validity was analyzed using exploratory factor analysis (EFA). The Kaiser-Meyer-Olkin (KMO) value was 0.749. Using Bartlett’s Sphericity test, the χ(2) (10) value was 198.257 (P<0.001). The factor loading coefficients of Spotter, Symbol Check, Codebreaker, and Trails on the common factor 1 were −0.724, 0.748, 0.824, and −0.717, respectively, and the factor loading coefficient of PDQ-5-D on the common factor 2 was 0.957. Results revealed that the correlation coefficient of the two common factors was 0.125. CONCLUSION: The THINC-it tool has good reliability and validity in assessing patients with bipolar depression.
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spelling pubmed-99834372023-03-04 Validation of the THINC-It Tool for Assessment of Cognitive Impairment in Patients with Bipolar Depression Zhu, Na Zhang, WeiHua Huang, Jia Su, Yousong Lu, JingFang Yang, Lu Shi, YiFan Hu, ShaoHua Chen, Jun Fang, Yiru Neuropsychiatr Dis Treat Original Research BACKGROUND: Cognitive impairment is one of the core features of bipolar depression. A unified, reliable, and valid assessment tool is key to screening and assessing cognitive impairment. The THINC-Integrated Tool (THINC-it) is a simple and quick battery for screening cognitive impairment in patients with major depressive disorder. However, the use of the tool has not been validated in patients with bipolar depression. METHODS: The cognitive functions of 120 patients with bipolar depression and 100 healthy controls were evaluated using the THINC-it tool including Spotter, Symbol Check, Codebreaker, Trials, and the only one subjective test (PDQ-5-D) and five corresponding standard tests. A psychometric analysis of the THINC-it tool was performed. RESULTS: The overall Cronbach’s alpha coefficient of the THINC-it tool was 0.815. The intra-group correlation coefficient (ICC) of retest reliability ranged from 0.571 to 0.854 (P<0.001), while the correlation r of parallel validity ranged from 0.291 to 0.921 (P<0.001). There were significant differences in the two groups Z-scores of THINC-it total score, Spotter, Codebreaker, Trails, and PDQ-5-D (P<0.05). Construct validity was analyzed using exploratory factor analysis (EFA). The Kaiser-Meyer-Olkin (KMO) value was 0.749. Using Bartlett’s Sphericity test, the χ(2) (10) value was 198.257 (P<0.001). The factor loading coefficients of Spotter, Symbol Check, Codebreaker, and Trails on the common factor 1 were −0.724, 0.748, 0.824, and −0.717, respectively, and the factor loading coefficient of PDQ-5-D on the common factor 2 was 0.957. Results revealed that the correlation coefficient of the two common factors was 0.125. CONCLUSION: The THINC-it tool has good reliability and validity in assessing patients with bipolar depression. Dove 2023-02-27 /pmc/articles/PMC9983437/ /pubmed/36874958 http://dx.doi.org/10.2147/NDT.S401095 Text en © 2023 Zhu et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Original Research
Zhu, Na
Zhang, WeiHua
Huang, Jia
Su, Yousong
Lu, JingFang
Yang, Lu
Shi, YiFan
Hu, ShaoHua
Chen, Jun
Fang, Yiru
Validation of the THINC-It Tool for Assessment of Cognitive Impairment in Patients with Bipolar Depression
title Validation of the THINC-It Tool for Assessment of Cognitive Impairment in Patients with Bipolar Depression
title_full Validation of the THINC-It Tool for Assessment of Cognitive Impairment in Patients with Bipolar Depression
title_fullStr Validation of the THINC-It Tool for Assessment of Cognitive Impairment in Patients with Bipolar Depression
title_full_unstemmed Validation of the THINC-It Tool for Assessment of Cognitive Impairment in Patients with Bipolar Depression
title_short Validation of the THINC-It Tool for Assessment of Cognitive Impairment in Patients with Bipolar Depression
title_sort validation of the thinc-it tool for assessment of cognitive impairment in patients with bipolar depression
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983437/
https://www.ncbi.nlm.nih.gov/pubmed/36874958
http://dx.doi.org/10.2147/NDT.S401095
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