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Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

BACKGROUND: Prucalopride is a selective serotonin type 4 (5-HT(4)) receptor agonist indicated for treatment of chronic idiopathic constipation (CIC) in adults (2 mg orally, daily). 5-HT(4) receptors are present in the central nervous system; therefore, non-clinical and clinical assessments were perf...

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Detalles Bibliográficos
Autores principales:	Derakhchan, Katayoun, Lou, Zhen, Wang, Hong, Baughman, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioExcel Publishing Ltd 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983627/ https://www.ncbi.nlm.nih.gov/pubmed/36876155 http://dx.doi.org/10.7573/dic.2022-6-1

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