Cargando…

Tissue distribution and abuse potential of prucalopride: findings from non-clinical and clinical studies

BACKGROUND: Prucalopride is a selective serotonin type 4 (5-HT(4)) receptor agonist indicated for treatment of chronic idiopathic constipation (CIC) in adults (2 mg orally, daily). 5-HT(4) receptors are present in the central nervous system; therefore, non-clinical and clinical assessments were perf...

Descripción completa

Detalles Bibliográficos
Autores principales:	Derakhchan, Katayoun, Lou, Zhen, Wang, Hong, Baughman, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioExcel Publishing Ltd 2023
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983627/ https://www.ncbi.nlm.nih.gov/pubmed/36876155 http://dx.doi.org/10.7573/dic.2022-6-1

Ejemplares similares

A Review of the Cardiovascular Safety of Prucalopride in Patients With Chronic Idiopathic Constipation
por: Tack, Jan, et al.
Publicado: (2023)

Clinical Efficacy and Safety Profile of Prucalopride in Chronic Idiopathic Constipation
por: Tameez Ud Din, Asim, et al.
Publicado: (2019)

Effect of prucalopride on symptoms of chronic constipation
por: Tack, J, et al.
Publicado: (2013)

The Effects of Prucalopride on Postoperative Ileus in Guinea Pigs
por: Park, Soo Jung, et al.
Publicado: (2013)

Effects of prucalopride on esophageal secondary peristalsis in humans
por: Yi, Chih-Hsun, et al.
Publicado: (2016)

Efficacy and Safety of Prucalopride in Chronic Constipation: An Integrated Analysis of Six Randomized, Controlled Clinical Trials
por: Camilleri, Michael, et al.
Publicado: (2016)

Prucalopride: the evidence for its use in the treatment of chronic constipation
por: Coremans, Georges
Publicado: (2008)

Effect of Prucalopride on the Pharmacokinetics of Oral Contraceptives in Healthy Women
por: Van de Velde, Vera, et al.
Publicado: (2013)

Cost-effectiveness of prucalopride in the treatment of chronic constipation in the Netherlands
por: Nuijten, Mark J. C., et al.
Publicado: (2015)

Patient considerations in the management of chronic constipation: focus on prucalopride
por: Shin, Andrea
Publicado: (2016)

Colon Capsule Visualization Is Not Enhanced with Prucalopride: A Randomized Controlled Trial
por: Hookey, Lawrence, et al.
Publicado: (2018)

Clinical comparison of ocular and systemic findings in diagnosed cases of abusive and non-abusive head trauma
por: Morgan, Linda A, et al.
Publicado: (2018)

Effect of prucalopride to improve time to gut function recovery following elective colorectal surgery: randomized clinical trial( )
por: Milne, Tony, et al.
Publicado: (2022)

Effects of Single-Dose Prucalopride on Intestinal Hypomotility in Horses: Preliminary Observations
por: Laus, Fulvio, et al.
Publicado: (2017)

Development of a population pharmacokinetic model of prucalopride in children with functional constipation
por: van Schaick, Erno, et al.
Publicado: (2016)

Role of Prucalopride in Treating Functional Constipation and Gastroparesis: A Systemic Review
por: Ali, Hassam, et al.
Publicado: (2021)

Current Opinion on Prucalopride in Gastroparesis and Chronic Constipation Treatment: A Focus on Patient Selection and Safety
por: Hong, Ji Taek
Publicado: (2021)

Response to letter: Balancing risks and benefits of prucalopride for the treatment of chronic constipation in Asians
por: Ke, M, et al.
Publicado: (2013)

Efficacy of Prucalopride in bowel cleansing before colonoscopy: Results of a pilot study
por: Corleto, Vito Domenico, et al.
Publicado: (2017)

The Effect of Prucalopride on the Completion Rate and Polyp Detection Rate of Colon Capsule Endoscopies
por: Deding, Ulrik, et al.
Publicado: (2022)

Efficacy and Safety of Prucalopride in Patients with Chronic Noncancer Pain Suffering from Opioid-Induced Constipation
por: Sloots, Cornelius E. J., et al.
Publicado: (2010)

Prucalopride inhibits the glioma cells proliferation and induces autophagy via AKT-mTOR pathway
por: Qiao, Hong, et al.
Publicado: (2018)

Radiosynthesis and preclinical evaluation of [(11)C]prucalopride as a potential agonist PET ligand for the 5-HT(4) receptor
por: Buiter, Hans JC, et al.
Publicado: (2013)

The Effect of Prucalopride on Small Bowel Transit Time in Hospitalized Patients Undergoing Capsule Endoscopy
por: Alsahafi, Majid, et al.
Publicado: (2017)

Prucalopride: A Recently Approved Drug by the Food and Drug Administration for Chronic Idiopathic Constipation
por: Mahajan, Rajiv
Publicado: (2019)

Cardiovascular Safety of Prucalopride in Patients with Chronic Constipation: A Multinational Population-Based Cohort Study
por: Gilsenan, Alicia, et al.
Publicado: (2019)

Role of prucalopride, a serotonin (5-HT(4)) receptor agonist, for the treatment of chronic constipation
por: Wong, Banny S, et al.
Publicado: (2010)

Prucalopride Improves Bowel Function and Colonic Transit Time in Patients With Chronic Constipation: An Integrated Analysis
por: Emmanuel, Anton, et al.
Publicado: (2014)

Different doses of prucalopride in treating chronic idiopathic constipation: a meta-analysis and Bayesian analysis
por: Yang, Tao, et al.
Publicado: (2021)

Efficacy of Prucalopride for Chronic Idiopathic Constipation: An Analysis of Participants With Moderate to Very Severe Abdominal Bloating
por: Staller, Kyle, et al.
Publicado: (2022)

Prucalopride might improve intestinal motility by promoting the regeneration of the enteric nervous system in diabetic rats
por: Wang, Yun, et al.
Publicado: (2022)

Effect of electroacupuncture versus prucalopride for severe chronic constipation: protocol of a multi-centre, non-inferiority, randomised controlled trial
por: Liu, Baoyan, et al.
Publicado: (2014)

Cannabis use, abuse, and withdrawal: Cannabinergic mechanisms, clinical, and preclinical findings
por: Kesner, Andrew J., et al.
Publicado: (2021)

Effect of Prucalopride in the Treatment of Chronic Constipation in Asian and Non-Asian Women: A Pooled Analysis of 4 Randomized, Placebo-controlled Studies
por: Ke, MeiYun, et al.
Publicado: (2014)

Effect of renal impairment on the pharmacokinetics of prucalopride: a single- dose open-label Phase I study
por: Smith, William B, et al.
Publicado: (2012)

Use of Prucalopride for Chronic Constipation: A Systematic Review and Meta-analysis of Published Randomized, Controlled Trials
por: Sajid, Muhammad S, et al.
Publicado: (2016)

Green microwave quantum dots as luminescent probes for quantifying prucalopride: consistency of content and application to pharmacokinetic studies
por: Salman, Baher I.
Publicado: (2023)

Bioanalytical Validated Spectrofluorimetric Method for the Determination of Prucalopride succinate in Human Urine Samples and Its Greenness Evaluation
por: Saad, Marwa T., et al.
Publicado: (2023)

Prucalopride in the treatment of chronic constipation in patients from the Asia-Pacific region: a randomized, double-blind, placebo-controlled study
por: Ke, M, et al.
Publicado: (2012)

Prucalopride reduces the number of reflux episodes and improves subjective symptoms in gastroesophageal reflux disease: a case series
por: Nennstiel, Simon, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_g7c7s9d4nlt22c5p1tle2dqaed