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Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study

To define benchmark values for liver transplantation (LT) in patients with perihilar cholangiocarcinoma (PHC) enabling unbiased comparisons. BACKGROUND: Transplantation for PHC is used with reluctance in many centers and even contraindicated in several countries. Although benchmark values for LT are...

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Autores principales: Breuer, Eva, Mueller, Matteo, Doyle, Majella B., Yang, Liu, Darwish Murad, Sarwa, Anwar, Imran J., Merani, Shaheed, Limkemann, Ashley, Jeddou, Heithem, Kim, Steven C., López-López, Victor, Nassar, Ahmed, Hoogwater, Frederik J.H., Vibert, Eric, De Oliveira, Michelle L., Cherqui, Daniel, Porte, Robert J., Magliocca, Joseph F., Fischer, Lutz, Fondevila, Constantino, Zieniewicz, Krzysztof, Ramírez, Pablo, Foley, David P., Boudjema, Karim, Schenk, Austin D., Langnas, Alan N., Knechtle, Stuart, Polak, Wojciech G., Taner, C. Burcin, Chapman, William C., Rosen, Charles B., Gores, Gregory J., Dutkowski, Philipp, Heimbach, Julie K., Clavien, Pierre-Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983747/
https://www.ncbi.nlm.nih.gov/pubmed/35894433
http://dx.doi.org/10.1097/SLA.0000000000005641
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author Breuer, Eva
Mueller, Matteo
Doyle, Majella B.
Yang, Liu
Darwish Murad, Sarwa
Anwar, Imran J.
Merani, Shaheed
Limkemann, Ashley
Jeddou, Heithem
Kim, Steven C.
López-López, Victor
Nassar, Ahmed
Hoogwater, Frederik J.H.
Vibert, Eric
De Oliveira, Michelle L.
Cherqui, Daniel
Porte, Robert J.
Magliocca, Joseph F.
Fischer, Lutz
Fondevila, Constantino
Zieniewicz, Krzysztof
Ramírez, Pablo
Foley, David P.
Boudjema, Karim
Schenk, Austin D.
Langnas, Alan N.
Knechtle, Stuart
Polak, Wojciech G.
Taner, C. Burcin
Chapman, William C.
Rosen, Charles B.
Gores, Gregory J.
Dutkowski, Philipp
Heimbach, Julie K.
Clavien, Pierre-Alain
author_facet Breuer, Eva
Mueller, Matteo
Doyle, Majella B.
Yang, Liu
Darwish Murad, Sarwa
Anwar, Imran J.
Merani, Shaheed
Limkemann, Ashley
Jeddou, Heithem
Kim, Steven C.
López-López, Victor
Nassar, Ahmed
Hoogwater, Frederik J.H.
Vibert, Eric
De Oliveira, Michelle L.
Cherqui, Daniel
Porte, Robert J.
Magliocca, Joseph F.
Fischer, Lutz
Fondevila, Constantino
Zieniewicz, Krzysztof
Ramírez, Pablo
Foley, David P.
Boudjema, Karim
Schenk, Austin D.
Langnas, Alan N.
Knechtle, Stuart
Polak, Wojciech G.
Taner, C. Burcin
Chapman, William C.
Rosen, Charles B.
Gores, Gregory J.
Dutkowski, Philipp
Heimbach, Julie K.
Clavien, Pierre-Alain
author_sort Breuer, Eva
collection PubMed
description To define benchmark values for liver transplantation (LT) in patients with perihilar cholangiocarcinoma (PHC) enabling unbiased comparisons. BACKGROUND: Transplantation for PHC is used with reluctance in many centers and even contraindicated in several countries. Although benchmark values for LT are available, there is a lack of specific data on LT performed for PHC. METHODS: PHC patients considered for LT after Mayo-like protocol were analyzed in 17 reference centers in 2 continents over the recent 5-year period (2014–2018). The minimum follow-up was 1 year. Benchmark patients were defined as operated at high-volume centers (≥50 overall LT/year) after neoadjuvant chemoradiotherapy, with a tumor diameter <3 cm, negative lymph nodes, and with the absence of relevant comorbidities. Benchmark cutoff values were derived from the 75th to 25th percentiles of the median values of all benchmark centers. RESULTS: One hundred thirty-four consecutive patients underwent LT after completion of the neoadjuvant treatment. Of those, 89.6% qualified as benchmark cases. Benchmark cutoffs were 90-day mortality ≤5.2%; comprehensive complication index at 1 year of ≤33.7; grade ≥3 complication rates ≤66.7%. These values were better than benchmark values for other indications of LT. Five-year disease-free survival was largely superior compared with a matched group of nodal negative patients undergoing curative liver resection (n=106) (62% vs 32%, P<0.001). CONCLUSION: This multicenter benchmark study demonstrates that LT offers excellent outcomes with superior oncological results in early stage PHC patients, even in candidates for surgery. This provocative observation should lead to a change in available therapeutic algorithms for PHC.
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spelling pubmed-99837472023-03-04 Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study Breuer, Eva Mueller, Matteo Doyle, Majella B. Yang, Liu Darwish Murad, Sarwa Anwar, Imran J. Merani, Shaheed Limkemann, Ashley Jeddou, Heithem Kim, Steven C. López-López, Victor Nassar, Ahmed Hoogwater, Frederik J.H. Vibert, Eric De Oliveira, Michelle L. Cherqui, Daniel Porte, Robert J. Magliocca, Joseph F. Fischer, Lutz Fondevila, Constantino Zieniewicz, Krzysztof Ramírez, Pablo Foley, David P. Boudjema, Karim Schenk, Austin D. Langnas, Alan N. Knechtle, Stuart Polak, Wojciech G. Taner, C. Burcin Chapman, William C. Rosen, Charles B. Gores, Gregory J. Dutkowski, Philipp Heimbach, Julie K. Clavien, Pierre-Alain Ann Surg ESA Paper To define benchmark values for liver transplantation (LT) in patients with perihilar cholangiocarcinoma (PHC) enabling unbiased comparisons. BACKGROUND: Transplantation for PHC is used with reluctance in many centers and even contraindicated in several countries. Although benchmark values for LT are available, there is a lack of specific data on LT performed for PHC. METHODS: PHC patients considered for LT after Mayo-like protocol were analyzed in 17 reference centers in 2 continents over the recent 5-year period (2014–2018). The minimum follow-up was 1 year. Benchmark patients were defined as operated at high-volume centers (≥50 overall LT/year) after neoadjuvant chemoradiotherapy, with a tumor diameter <3 cm, negative lymph nodes, and with the absence of relevant comorbidities. Benchmark cutoff values were derived from the 75th to 25th percentiles of the median values of all benchmark centers. RESULTS: One hundred thirty-four consecutive patients underwent LT after completion of the neoadjuvant treatment. Of those, 89.6% qualified as benchmark cases. Benchmark cutoffs were 90-day mortality ≤5.2%; comprehensive complication index at 1 year of ≤33.7; grade ≥3 complication rates ≤66.7%. These values were better than benchmark values for other indications of LT. Five-year disease-free survival was largely superior compared with a matched group of nodal negative patients undergoing curative liver resection (n=106) (62% vs 32%, P<0.001). CONCLUSION: This multicenter benchmark study demonstrates that LT offers excellent outcomes with superior oncological results in early stage PHC patients, even in candidates for surgery. This provocative observation should lead to a change in available therapeutic algorithms for PHC. Lippincott Williams & Wilkins 2022-11 2022-07-27 /pmc/articles/PMC9983747/ /pubmed/35894433 http://dx.doi.org/10.1097/SLA.0000000000005641 Text en Copyright © 2022 The Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/)
spellingShingle ESA Paper
Breuer, Eva
Mueller, Matteo
Doyle, Majella B.
Yang, Liu
Darwish Murad, Sarwa
Anwar, Imran J.
Merani, Shaheed
Limkemann, Ashley
Jeddou, Heithem
Kim, Steven C.
López-López, Victor
Nassar, Ahmed
Hoogwater, Frederik J.H.
Vibert, Eric
De Oliveira, Michelle L.
Cherqui, Daniel
Porte, Robert J.
Magliocca, Joseph F.
Fischer, Lutz
Fondevila, Constantino
Zieniewicz, Krzysztof
Ramírez, Pablo
Foley, David P.
Boudjema, Karim
Schenk, Austin D.
Langnas, Alan N.
Knechtle, Stuart
Polak, Wojciech G.
Taner, C. Burcin
Chapman, William C.
Rosen, Charles B.
Gores, Gregory J.
Dutkowski, Philipp
Heimbach, Julie K.
Clavien, Pierre-Alain
Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study
title Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study
title_full Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study
title_fullStr Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study
title_full_unstemmed Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study
title_short Liver Transplantation as a New Standard of Care in Patients With Perihilar Cholangiocarcinoma? Results From an International Benchmark Study
title_sort liver transplantation as a new standard of care in patients with perihilar cholangiocarcinoma? results from an international benchmark study
topic ESA Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983747/
https://www.ncbi.nlm.nih.gov/pubmed/35894433
http://dx.doi.org/10.1097/SLA.0000000000005641
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