Effects of theophylline on ADCY5 activation—From cellular studies to improved therapeutic options for ADCY5-related dyskinesia patients

We show the effects of the three purine derivatives, caffeine, theophylline, and istradefylline, on cAMP production by adenylyl cyclase 5 (ADCY5)-overexpressing cell lines. A comparison of cAMP levels was performed for ADCY5 wild-type and R418W mutant cells. ADCY5-catalyzed cAMP production was reduc...

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Detalles Bibliográficos
Autores principales: Tänzler, Dirk, Kipping, Marc, Lederer, Marcell, Günther, Wiebke F., Arlt, Christian, Hüttelmaier, Stefan, Merkenschlager, Andreas, Sinz, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983822/
https://www.ncbi.nlm.nih.gov/pubmed/36867608
http://dx.doi.org/10.1371/journal.pone.0282593

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983822/
https://www.ncbi.nlm.nih.gov/pubmed/36867608
http://dx.doi.org/10.1371/journal.pone.0282593

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