Suppression of cGAS- and RIG-I-mediated innate immune signaling by Epstein-Barr virus deubiquitinase BPLF1

Epstein-Barr virus (EBV) has developed effective strategies to evade host innate immune responses. Here we reported on mitigation of type I interferon (IFN) production by EBV deubiquitinase (DUB) BPLF1 through cGAS-STING and RIG-I-MAVS pathways. The two naturally occurring forms of BPLF1 exerted pot...

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Detalles Bibliográficos
Autores principales: Lui, Wai-Yin, Bharti, Aradhana, Wong, Nok-Hei Mickey, Jangra, Sonia, Botelho, Michael G., Yuen, Kit-San, Jin, Dong-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9983872/
https://www.ncbi.nlm.nih.gov/pubmed/36802409
http://dx.doi.org/10.1371/journal.ppat.1011186

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