Memory of stochastic single-cell apoptotic signaling promotes chemoresistance in neuroblastoma

Gene expression noise is known to promote stochastic drug resistance through the elevated expression of individual genes in rare cancer cells. However, we now demonstrate that chemoresistant neuroblastoma cells emerge at a much higher frequency when the influence of noise is integrated across multip...

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Detalles Bibliográficos
Autores principales: Hastings, Jordan F., Latham, Sharissa L., Kamili, Alvin, Wheatley, Madeleine S., Han, Jeremy Z. R., Wong-Erasmus, Marie, Phimmachanh, Monica, Nobis, Max, Pantarelli, Chiara, Cadell, Antonia L., O’Donnell, Yolande E. I., Leong, King Ho, Lynn, Sophie, Geng, Fan-Suo, Cui, Lujing, Yan, Sabrina, Achinger-Kawecka, Joanna, Stirzaker, Clare, Norris, Murray D., Haber, Michelle, Trahair, Toby N., Speleman, Frank, De Preter, Katleen, Cowley, Mark J., Bogdanovic, Ozren, Timpson, Paul, Cox, Thomas R., Kolch, Walter, Fletcher, Jamie I., Fey, Dirk, Croucher, David R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984174/
https://www.ncbi.nlm.nih.gov/pubmed/36867694
http://dx.doi.org/10.1126/sciadv.abp8314

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