CREB3L2-ATF4 heterodimerization defines a transcriptional hub of Alzheimer’s disease gene expression linked to neuropathology

Gene expression is changed by disease, but how these molecular responses arise and contribute to pathophysiology remains less understood. We discover that β-amyloid, a trigger of Alzheimer’s disease (AD), promotes the formation of pathological CREB3L2-ATF4 transcription factor heterodimers in neuron...

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Detalles Bibliográficos
Autores principales: Gouveia Roque, Cláudio, Chung, Kyung Min, McCurdy, Ethan P., Jagannathan, Radhika, Randolph, Lisa K., Herline-Killian, Krystal, Baleriola, Jimena, Hengst, Ulrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984184/
https://www.ncbi.nlm.nih.gov/pubmed/36867706
http://dx.doi.org/10.1126/sciadv.add2671

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