Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report

We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complicated by ba...

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Autores principales: Passerotto, Rosa Anna, Lamanna, Francesco, Farinacci, Damiano, Dusina, Alex, Di Giambenedetto, Simona, Ciccullo, Arturo, Borghetti, Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd on behalf of Tsinghua University Press. 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984230/
https://www.ncbi.nlm.nih.gov/pubmed/38013739
http://dx.doi.org/10.1016/j.imj.2023.02.004
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author Passerotto, Rosa Anna
Lamanna, Francesco
Farinacci, Damiano
Dusina, Alex
Di Giambenedetto, Simona
Ciccullo, Arturo
Borghetti, Alberto
author_facet Passerotto, Rosa Anna
Lamanna, Francesco
Farinacci, Damiano
Dusina, Alex
Di Giambenedetto, Simona
Ciccullo, Arturo
Borghetti, Alberto
author_sort Passerotto, Rosa Anna
collection PubMed
description We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complicated by bacteraemic ventilator-associated pneumonia (VAP) caused by multidrug-resistant Acinetobacter baumannii (MDR-AB) isolated on pleural fluid culture, treated with colistin and cefiderocol for about 3 weeks. The molecular research of MDR-AB on transtracheal aspirate was negative following this therapy. The aim is to show the safety, efficacy and tolerability of colistin-based combination therapy with cefiderocol for Acinetobacter baumannii infection in HIV-infected patient.
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spelling pubmed-99842302023-03-06 Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report Passerotto, Rosa Anna Lamanna, Francesco Farinacci, Damiano Dusina, Alex Di Giambenedetto, Simona Ciccullo, Arturo Borghetti, Alberto Infectious Medicine Case Report We analyzed the case of a 49-year-old woman with HIV infection off-therapy with poor viro-immunological compensation, not vaccinated for SARS-COV-2, hospitalized for lobar pneumonia and severe COVID19-related respiratory failure in intensive care unit (ICU). The hospitalization was complicated by bacteraemic ventilator-associated pneumonia (VAP) caused by multidrug-resistant Acinetobacter baumannii (MDR-AB) isolated on pleural fluid culture, treated with colistin and cefiderocol for about 3 weeks. The molecular research of MDR-AB on transtracheal aspirate was negative following this therapy. The aim is to show the safety, efficacy and tolerability of colistin-based combination therapy with cefiderocol for Acinetobacter baumannii infection in HIV-infected patient. The Authors. Published by Elsevier Ltd on behalf of Tsinghua University Press. 2023-06 2023-03-04 /pmc/articles/PMC9984230/ /pubmed/38013739 http://dx.doi.org/10.1016/j.imj.2023.02.004 Text en © 2023 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Case Report
Passerotto, Rosa Anna
Lamanna, Francesco
Farinacci, Damiano
Dusina, Alex
Di Giambenedetto, Simona
Ciccullo, Arturo
Borghetti, Alberto
Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report
title Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report
title_full Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report
title_fullStr Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report
title_full_unstemmed Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report
title_short Ventilator-associated pneumonia (VAP) and pleural empyema caused by multidrug-resistant Acinetobacter baumannii in HIV and COVID 19 infected patient: A case report
title_sort ventilator-associated pneumonia (vap) and pleural empyema caused by multidrug-resistant acinetobacter baumannii in hiv and covid 19 infected patient: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984230/
https://www.ncbi.nlm.nih.gov/pubmed/38013739
http://dx.doi.org/10.1016/j.imj.2023.02.004
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