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Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis with higher risk for polyneuropathy?

BACKGROUND: With the introduction of several drugs for the therapy of transthyretin-related amyloidosis (ATTR) which slow down the disease, early detection of polyneuropathy (PNP) is becoming increasingly of interest. [99mTc]-3,3-Diphosphono-1,2-Propanodicarboxylic Acid (DPD) bone scintigraphy, whic...

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Autores principales: Wollenweber, Tim, Kretschmer-Chott, Elisabeth, Wurm, Raphael, Rasul, Sazan, Kulterer, Oana, Rettl, Rene, Duca, Franz, Bonderman, Diana, Sühs, Kurt-Wolfram, Hacker, Marcus, Traub-Weidinger, Tatjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984356/
https://www.ncbi.nlm.nih.gov/pubmed/35817943
http://dx.doi.org/10.1007/s12350-022-02986-7
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author Wollenweber, Tim
Kretschmer-Chott, Elisabeth
Wurm, Raphael
Rasul, Sazan
Kulterer, Oana
Rettl, Rene
Duca, Franz
Bonderman, Diana
Sühs, Kurt-Wolfram
Hacker, Marcus
Traub-Weidinger, Tatjana
author_facet Wollenweber, Tim
Kretschmer-Chott, Elisabeth
Wurm, Raphael
Rasul, Sazan
Kulterer, Oana
Rettl, Rene
Duca, Franz
Bonderman, Diana
Sühs, Kurt-Wolfram
Hacker, Marcus
Traub-Weidinger, Tatjana
author_sort Wollenweber, Tim
collection PubMed
description BACKGROUND: With the introduction of several drugs for the therapy of transthyretin-related amyloidosis (ATTR) which slow down the disease, early detection of polyneuropathy (PNP) is becoming increasingly of interest. [99mTc]-3,3-Diphosphono-1,2-Propanodicarboxylic Acid (DPD) bone scintigraphy, which is used for the diagnosis of cardiac (c)ATTR, can possibly make an important contribution in the identification of patients at risk for PNP. METHODS: Fifty patients with cATTR, who underwent both planar whole-body DPD scintigraphy and nerve conduction studies (NCS) were retrospectively evaluated. A subgroup of 22 patients also underwent quantitative SPECT/CT of the thorax from which Standardized Uptake Values (SUVpeak) in the subcutaneous fat tissue of the left axillar region were evaluated. RESULTS: The Perugini score was significantly increased in patients with cATTR and additional diagnosis of PNP compared to patients without (2.51 ± 0.51 vs 2.13 ± 0.52; P = 0.03). Quantitative SPECT/CT revealed that DPD uptake in the subcutaneous fat of the left axillar region was significantly increased in cATTR patients with compared to patients without (1.36 ± 0.60 vs 0.74 ± 0.52; P = 0.04). CONCLUSION: This study suggests that DPD bone scintigraphy is a useful tool for identification of patients with cATTR and a risk for PNP due to increased DPD soft tissue uptake. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12350-022-02986-7.
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spelling pubmed-99843562023-03-05 Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis with higher risk for polyneuropathy? Wollenweber, Tim Kretschmer-Chott, Elisabeth Wurm, Raphael Rasul, Sazan Kulterer, Oana Rettl, Rene Duca, Franz Bonderman, Diana Sühs, Kurt-Wolfram Hacker, Marcus Traub-Weidinger, Tatjana J Nucl Cardiol Original Article BACKGROUND: With the introduction of several drugs for the therapy of transthyretin-related amyloidosis (ATTR) which slow down the disease, early detection of polyneuropathy (PNP) is becoming increasingly of interest. [99mTc]-3,3-Diphosphono-1,2-Propanodicarboxylic Acid (DPD) bone scintigraphy, which is used for the diagnosis of cardiac (c)ATTR, can possibly make an important contribution in the identification of patients at risk for PNP. METHODS: Fifty patients with cATTR, who underwent both planar whole-body DPD scintigraphy and nerve conduction studies (NCS) were retrospectively evaluated. A subgroup of 22 patients also underwent quantitative SPECT/CT of the thorax from which Standardized Uptake Values (SUVpeak) in the subcutaneous fat tissue of the left axillar region were evaluated. RESULTS: The Perugini score was significantly increased in patients with cATTR and additional diagnosis of PNP compared to patients without (2.51 ± 0.51 vs 2.13 ± 0.52; P = 0.03). Quantitative SPECT/CT revealed that DPD uptake in the subcutaneous fat of the left axillar region was significantly increased in cATTR patients with compared to patients without (1.36 ± 0.60 vs 0.74 ± 0.52; P = 0.04). CONCLUSION: This study suggests that DPD bone scintigraphy is a useful tool for identification of patients with cATTR and a risk for PNP due to increased DPD soft tissue uptake. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12350-022-02986-7. Springer International Publishing 2022-07-11 2023 /pmc/articles/PMC9984356/ /pubmed/35817943 http://dx.doi.org/10.1007/s12350-022-02986-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Wollenweber, Tim
Kretschmer-Chott, Elisabeth
Wurm, Raphael
Rasul, Sazan
Kulterer, Oana
Rettl, Rene
Duca, Franz
Bonderman, Diana
Sühs, Kurt-Wolfram
Hacker, Marcus
Traub-Weidinger, Tatjana
Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis with higher risk for polyneuropathy?
title Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis with higher risk for polyneuropathy?
title_full Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis with higher risk for polyneuropathy?
title_fullStr Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis with higher risk for polyneuropathy?
title_full_unstemmed Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis with higher risk for polyneuropathy?
title_short Does [99mTc]-3,3-diphosphono-1,2-propanodicarboxylic acid (DPD) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (ATTR) amyloidosis with higher risk for polyneuropathy?
title_sort does [99mtc]-3,3-diphosphono-1,2-propanodicarboxylic acid (dpd) soft tissue uptake allow the identification of patients with the diagnosis of cardiac transthyretin-related (attr) amyloidosis with higher risk for polyneuropathy?
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984356/
https://www.ncbi.nlm.nih.gov/pubmed/35817943
http://dx.doi.org/10.1007/s12350-022-02986-7
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