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Quantitative analysis of C. elegans transcripts by Nanopore direct-cDNA sequencing reveals terminal hairpins in non trans-spliced mRNAs

In nematodes and kinetoplastids, mRNA processing involves a trans-splicing step through which a short sequence from a snRNP replaces the original 5’ end of the primary transcript. It has long been held that 70% of C. elegans mRNAs are submitted to trans-splicing. Our recent work suggested that the m...

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Detalles Bibliográficos
Autores principales: Bernard, Florian, Dargère, Delphine, Rechavi, Oded, Dupuy, Denis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984361/
https://www.ncbi.nlm.nih.gov/pubmed/36869073
http://dx.doi.org/10.1038/s41467-023-36915-0