Tandem mass tag-based quantitative proteomic profiling identifies candidate serum biomarkers of drug-induced liver injury in humans

Diagnosis of drug-induced liver injury (DILI) and its distinction from other liver diseases are significant challenges in drug development and clinical practice. Here, we identify, confirm, and replicate the biomarker performance characteristics of candidate proteins in patients with DILI at onset (...

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Detalles Bibliográficos
Autores principales: Ravindra, Kodihalli C., Vaidya, Vishal S., Wang, Zhenyu, Federspiel, Joel D., Virgen-Slane, Richard, Everley, Robert A., Grove, Jane I., Stephens, Camilla, Ocana, Mireia F., Robles-Díaz, Mercedes, Isabel Lucena, M., Andrade, Raul J., Atallah, Edmond, Gerbes, Alexander L., Weber, Sabine, Cortez-Pinto, Helena, Fowell, Andrew J., Hussaini, Hyder, Bjornsson, Einar S., Patel, Janisha, Stirnimann, Guido, Verma, Sumita, Elsharkawy, Ahmed M., Griffiths, William J. H., Hyde, Craig, Dear, James W., Aithal, Guruprasad P., Ramaiah, Shashi K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984368/
https://www.ncbi.nlm.nih.gov/pubmed/36869085
http://dx.doi.org/10.1038/s41467-023-36858-6

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