An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping

Genetic sharing is extensively observed for autoimmune diseases, but the causal variants and their underlying molecular mechanisms remain largely unknown. Through systematic investigation of autoimmune disease pleiotropic loci, we found most of these shared genetic effects are transmitted from regul...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Zhao, Liang, Qian, Qian, Xinyi, Hu, Bolang, Zheng, Zhanye, Wang, Jianhua, Hu, Yuelin, Bao, Zhengkai, Zhao, Ke, Zhou, Yao, Feng, Xiangling, Yi, Xianfu, Li, Jin, Shi, Jiandang, Liu, Zhe, Hao, Jihui, Chen, Kexin, Yu, Ying, Sham, Pak Chung, Lu, Wange, Wang, Xiaoyan, Song, Weihong, Li, Mulin Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984425/
https://www.ncbi.nlm.nih.gov/pubmed/36869052
http://dx.doi.org/10.1038/s41467-023-36897-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984425/
https://www.ncbi.nlm.nih.gov/pubmed/36869052
http://dx.doi.org/10.1038/s41467-023-36897-z

Ejemplares similares