An Igh distal enhancer modulates antigen receptor diversity by determining locus conformation

The mouse Igh locus is organized into a developmentally regulated topologically associated domain (TAD) that is divided into subTADs. Here we identify a series of distal V(H) enhancers (E(VH)s) that collaborate to configure the locus. E(VH)s engage in a network of long-range interactions that interc...

Descripción completa

Detalles Bibliográficos
Autores principales: Bhat, Khalid H., Priyadarshi, Saurabh, Naiyer, Sarah, Qu, Xinyan, Farooq, Hammad, Kleiman, Eden, Xu, Jeffery, Lei, Xue, Cantillo, Jose F., Wuerffel, Robert, Baumgarth, Nicole, Liang, Jie, Feeney, Ann J., Kenter, Amy L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984487/
https://www.ncbi.nlm.nih.gov/pubmed/36869028
http://dx.doi.org/10.1038/s41467-023-36414-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984487/
https://www.ncbi.nlm.nih.gov/pubmed/36869028
http://dx.doi.org/10.1038/s41467-023-36414-2

Ejemplares similares