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Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography

BACKGROUND: Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel R...

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Autores principales: Jones, K. A., Paterson, C. A., Ray, S., Motherwell, D. W., Hamilton, D. J., Small, A. D., Martin, W., Goodfield, N. E. R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984517/
https://www.ncbi.nlm.nih.gov/pubmed/36417121
http://dx.doi.org/10.1007/s12350-022-03142-x
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author Jones, K. A.
Paterson, C. A.
Ray, S.
Motherwell, D. W.
Hamilton, D. J.
Small, A. D.
Martin, W.
Goodfield, N. E. R.
author_facet Jones, K. A.
Paterson, C. A.
Ray, S.
Motherwell, D. W.
Hamilton, D. J.
Small, A. D.
Martin, W.
Goodfield, N. E. R.
author_sort Jones, K. A.
collection PubMed
description BACKGROUND: Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel RNVG phase parameters. METHODS: A retrospective study was carried out in a group of 98 patients with HFrEF. LVEF and dyssynchrony were assessed pre and post beta-blockade. Dyssynchrony was assessed using synchrony, entropy, phase standard deviation, approximate entropy, and sample entropy from planar RNVG phase images. Subgroups split by ischemic etiology were also investigated. RESULTS: An improvement in dyssynchrony and LVEF was measured six months post beta-blockade for both ischemic and non-ischemic groups. CONCLUSIONS: A significant improvement in dyssynchrony and LVEF was measured post beta-blockade using novel measures of dyssynchrony.
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spelling pubmed-99845172023-03-05 Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography Jones, K. A. Paterson, C. A. Ray, S. Motherwell, D. W. Hamilton, D. J. Small, A. D. Martin, W. Goodfield, N. E. R. J Nucl Cardiol Original Article BACKGROUND: Radionuclide ventriculography (RNVG) can be used to quantify mechanical dyssynchrony and may be a valuable adjunct in the assessment of heart failure with reduced ejection fraction (HFrEF). The study aims to investigate the effect of beta-blockers on mechanical dyssynchrony using novel RNVG phase parameters. METHODS: A retrospective study was carried out in a group of 98 patients with HFrEF. LVEF and dyssynchrony were assessed pre and post beta-blockade. Dyssynchrony was assessed using synchrony, entropy, phase standard deviation, approximate entropy, and sample entropy from planar RNVG phase images. Subgroups split by ischemic etiology were also investigated. RESULTS: An improvement in dyssynchrony and LVEF was measured six months post beta-blockade for both ischemic and non-ischemic groups. CONCLUSIONS: A significant improvement in dyssynchrony and LVEF was measured post beta-blockade using novel measures of dyssynchrony. Springer International Publishing 2022-11-23 2023 /pmc/articles/PMC9984517/ /pubmed/36417121 http://dx.doi.org/10.1007/s12350-022-03142-x Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Original Article
Jones, K. A.
Paterson, C. A.
Ray, S.
Motherwell, D. W.
Hamilton, D. J.
Small, A. D.
Martin, W.
Goodfield, N. E. R.
Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography
title Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography
title_full Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography
title_fullStr Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography
title_full_unstemmed Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography
title_short Beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography
title_sort beta-blockers and mechanical dyssynchrony in heart failure assessed by radionuclide ventriculography
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984517/
https://www.ncbi.nlm.nih.gov/pubmed/36417121
http://dx.doi.org/10.1007/s12350-022-03142-x
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