The Wnt/TCF7L1 transcriptional repressor axis drives primitive endoderm formation by antagonizing naive and formative pluripotency

Early during preimplantation development and in heterogeneous mouse embryonic stem cells (mESC) culture, pluripotent cells are specified towards either the primed epiblast or the primitive endoderm (PE) lineage. Canonical Wnt signaling is crucial for safeguarding naive pluripotency and embryo implan...

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Detalles Bibliográficos
Autores principales: Athanasouli, Paraskevi, Balli, Martina, De Jaime-Soguero, Anchel, Boel, Annekatrien, Papanikolaou, Sofia, van der Veer, Bernard K., Janiszewski, Adrian, Vanhessche, Tijs, Francis, Annick, El Laithy, Youssef, Nigro, Antonio Lo, Aulicino, Francesco, Koh, Kian Peng, Pasque, Vincent, Cosma, Maria Pia, Verfaillie, Catherine, Zwijsen, An, Heindryckx, Björn, Nikolaou, Christoforos, Lluis, Frederic
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984534/
https://www.ncbi.nlm.nih.gov/pubmed/36869101
http://dx.doi.org/10.1038/s41467-023-36914-1

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