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Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing

3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emergin...

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Autores principales: Rodríguez-Pombo, Lucía, Martínez-Castro, Laura, Xu, Xiaoyan, Ong, Jun Jie, Rial, Carlos, García, Daniel Nieto, González-Santos, Alejandro, Flores-González, Julian, Alvarez-Lorenzo, Carmen, Basit, Abdul W., Goyanes, Alvaro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984549/
https://www.ncbi.nlm.nih.gov/pubmed/36880028
http://dx.doi.org/10.1016/j.ijpx.2023.100166
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author Rodríguez-Pombo, Lucía
Martínez-Castro, Laura
Xu, Xiaoyan
Ong, Jun Jie
Rial, Carlos
García, Daniel Nieto
González-Santos, Alejandro
Flores-González, Julian
Alvarez-Lorenzo, Carmen
Basit, Abdul W.
Goyanes, Alvaro
author_facet Rodríguez-Pombo, Lucía
Martínez-Castro, Laura
Xu, Xiaoyan
Ong, Jun Jie
Rial, Carlos
García, Daniel Nieto
González-Santos, Alejandro
Flores-González, Julian
Alvarez-Lorenzo, Carmen
Basit, Abdul W.
Goyanes, Alvaro
author_sort Rodríguez-Pombo, Lucía
collection PubMed
description 3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emerging 3D printing technology that affords such speeds, being capable of producing entire objects within seconds. In this study, for the first time, rotatory volumetric printing was used to simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as the model drug, poly(ethylene glycol) diacrylate (PEGDA) 575 or 700 as photoreactive monomers, water and PEG 300 as non-reactive diluents, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator were investigated. Two printlets were successfully printed in 12 to 32 s and exhibited sustained drug release profiles. These results support the use of rotary volumetric printing for efficient and effective manufacturing of various personalised medicines at the same time. With the speed and precision it affords, rotatory volumetric printing has the potential to become one of the most promising alternative manufacturing technologies in the pharmaceutical industry.
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spelling pubmed-99845492023-03-05 Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing Rodríguez-Pombo, Lucía Martínez-Castro, Laura Xu, Xiaoyan Ong, Jun Jie Rial, Carlos García, Daniel Nieto González-Santos, Alejandro Flores-González, Julian Alvarez-Lorenzo, Carmen Basit, Abdul W. Goyanes, Alvaro Int J Pharm X Special Issue on Latest trends in pharmaceutical printing 3D printing is driving a shift in patient care away from a generalised model and towards personalised treatments. To complement fast-paced clinical environments, 3D printing technologies must provide sufficiently high throughputs for them to be feasibly implemented. Volumetric printing is an emerging 3D printing technology that affords such speeds, being capable of producing entire objects within seconds. In this study, for the first time, rotatory volumetric printing was used to simultaneously produce two torus- or cylinder-shaped paracetamol-loaded Printlets (3D printed tablets). Six resin formulations comprising paracetamol as the model drug, poly(ethylene glycol) diacrylate (PEGDA) 575 or 700 as photoreactive monomers, water and PEG 300 as non-reactive diluents, and lithium phenyl-2,4,6-trimethylbenzoylphosphinate (LAP) as the photoinitiator were investigated. Two printlets were successfully printed in 12 to 32 s and exhibited sustained drug release profiles. These results support the use of rotary volumetric printing for efficient and effective manufacturing of various personalised medicines at the same time. With the speed and precision it affords, rotatory volumetric printing has the potential to become one of the most promising alternative manufacturing technologies in the pharmaceutical industry. Elsevier 2023-02-08 /pmc/articles/PMC9984549/ /pubmed/36880028 http://dx.doi.org/10.1016/j.ijpx.2023.100166 Text en © 2023 The Authors. Published by Elsevier B.V. https://creativecommons.org/licenses/by/4.0/This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Special Issue on Latest trends in pharmaceutical printing
Rodríguez-Pombo, Lucía
Martínez-Castro, Laura
Xu, Xiaoyan
Ong, Jun Jie
Rial, Carlos
García, Daniel Nieto
González-Santos, Alejandro
Flores-González, Julian
Alvarez-Lorenzo, Carmen
Basit, Abdul W.
Goyanes, Alvaro
Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title_full Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title_fullStr Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title_full_unstemmed Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title_short Simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3D printing
title_sort simultaneous fabrication of multiple tablets within seconds using tomographic volumetric 3d printing
topic Special Issue on Latest trends in pharmaceutical printing
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984549/
https://www.ncbi.nlm.nih.gov/pubmed/36880028
http://dx.doi.org/10.1016/j.ijpx.2023.100166
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