Experimental evidence and clinical implications of Warburg effect in the skeletal muscle of Fabry disease

Skeletal muscle (SM) pain and fatigue are common in Fabry disease (FD). Here, we undertook the investigation of the energetic mechanisms related to FD-SM phenotype. A reduced tolerance to aerobic activity and lactate accumulation occurred in FD-mice and patients. Accordingly, in murine FD-SM we dete...

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Detalles Bibliográficos
Autores principales: Gambardella, Jessica, Fiordelisi, Antonella, Cerasuolo, Federica Andrea, Buonaiuto, Antonietta, Avvisato, Roberta, Viti, Alessandro, Sommella, Eduardo, Merciai, Fabrizio, Salviati, Emanuela, Campiglia, Pietro, D’Argenio, Valeria, Parisi, Silvia, Bianco, Antonio, Spinelli, Letizia, Di Vaia, Eugenio, Cuocolo, Alberto, Pisani, Antonio, Riccio, Eleonora, Di Risi, Teodolinda, Ciccarelli, Michele, Santulli, Gaetano, Sorriento, Daniela, Iaccarino, Guido
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984560/
https://www.ncbi.nlm.nih.gov/pubmed/36879801
http://dx.doi.org/10.1016/j.isci.2023.106074

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