Transient Parvovirus B19 DNAemia After Kidney Transplantation: A 2-Sided Story

Parvovirus B19 (B19V) DNAemia appears to be a relatively common finding after kidney transplantation. However, not all DNAemia signifies active infection with replicating virus. This study screened 134 patients posttransplantation for B19V DNAemia and identified 2 cases in which viral DNA was presen...

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Autores principales: Russcher, Anne, Molenaar-de Backer, Marijke, de Brouwer, Caroline, Dijkstra, Kyra, Kers, Jesper, de Vries, Aiko, Zaaijer, Hans, Vossen, Ann, Kroes, Aloysius
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984985/
https://www.ncbi.nlm.nih.gov/pubmed/36879626
http://dx.doi.org/10.1093/ofid/ofad079
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author Russcher, Anne
Molenaar-de Backer, Marijke
de Brouwer, Caroline
Dijkstra, Kyra
Kers, Jesper
de Vries, Aiko
Zaaijer, Hans
Vossen, Ann
Kroes, Aloysius
author_facet Russcher, Anne
Molenaar-de Backer, Marijke
de Brouwer, Caroline
Dijkstra, Kyra
Kers, Jesper
de Vries, Aiko
Zaaijer, Hans
Vossen, Ann
Kroes, Aloysius
author_sort Russcher, Anne
collection PubMed
description Parvovirus B19 (B19V) DNAemia appears to be a relatively common finding after kidney transplantation. However, not all DNAemia signifies active infection with replicating virus. This study screened 134 patients posttransplantation for B19V DNAemia and identified 2 cases in which viral DNA was present after transplantation, with the donor kidney as probable source of the DNA. In both cases intact viral particles could not be detected using an endonuclease method, indicating the presence of noninfectious DNA remnants.
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spelling pubmed-99849852023-03-05 Transient Parvovirus B19 DNAemia After Kidney Transplantation: A 2-Sided Story Russcher, Anne Molenaar-de Backer, Marijke de Brouwer, Caroline Dijkstra, Kyra Kers, Jesper de Vries, Aiko Zaaijer, Hans Vossen, Ann Kroes, Aloysius Open Forum Infect Dis Brief Report Parvovirus B19 (B19V) DNAemia appears to be a relatively common finding after kidney transplantation. However, not all DNAemia signifies active infection with replicating virus. This study screened 134 patients posttransplantation for B19V DNAemia and identified 2 cases in which viral DNA was present after transplantation, with the donor kidney as probable source of the DNA. In both cases intact viral particles could not be detected using an endonuclease method, indicating the presence of noninfectious DNA remnants. Oxford University Press 2023-02-14 /pmc/articles/PMC9984985/ /pubmed/36879626 http://dx.doi.org/10.1093/ofid/ofad079 Text en © The Author(s) 2023. Published by Oxford University Press on behalf of Infectious Diseases Society of America. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (https://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Russcher, Anne
Molenaar-de Backer, Marijke
de Brouwer, Caroline
Dijkstra, Kyra
Kers, Jesper
de Vries, Aiko
Zaaijer, Hans
Vossen, Ann
Kroes, Aloysius
Transient Parvovirus B19 DNAemia After Kidney Transplantation: A 2-Sided Story
title Transient Parvovirus B19 DNAemia After Kidney Transplantation: A 2-Sided Story
title_full Transient Parvovirus B19 DNAemia After Kidney Transplantation: A 2-Sided Story
title_fullStr Transient Parvovirus B19 DNAemia After Kidney Transplantation: A 2-Sided Story
title_full_unstemmed Transient Parvovirus B19 DNAemia After Kidney Transplantation: A 2-Sided Story
title_short Transient Parvovirus B19 DNAemia After Kidney Transplantation: A 2-Sided Story
title_sort transient parvovirus b19 dnaemia after kidney transplantation: a 2-sided story
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984985/
https://www.ncbi.nlm.nih.gov/pubmed/36879626
http://dx.doi.org/10.1093/ofid/ofad079
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