Protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization for wound healing in rats

Here, we present a protocol for controllable biomimetic mineralization at the nano-scale, simulating natural ion-enriched sedimentary mineralization. We describe steps for treatment of metal-organic frameworks with polyphenol-mediated stabilized mineralized precursor solution. We then detail their u...

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Detalles Bibliográficos
Autores principales: Zhan, Xiaolong, Wen, Zhengbo, Chen, Yuxin, Feng, Jiaxin, Liang, Ke, Xue, Liecong, He, Peiying, Chen, Honglin, Zhu, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Protocol
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985021/
https://www.ncbi.nlm.nih.gov/pubmed/36861839
http://dx.doi.org/10.1016/j.xpro.2023.102131
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author Zhan, Xiaolong
Wen, Zhengbo
Chen, Yuxin
Feng, Jiaxin
Liang, Ke
Xue, Liecong
He, Peiying
Chen, Honglin
Zhu, Wei
author_facet Zhan, Xiaolong
Wen, Zhengbo
Chen, Yuxin
Feng, Jiaxin
Liang, Ke
Xue, Liecong
He, Peiying
Chen, Honglin
Zhu, Wei
author_sort Zhan, Xiaolong
collection PubMed
description Here, we present a protocol for controllable biomimetic mineralization at the nano-scale, simulating natural ion-enriched sedimentary mineralization. We describe steps for treatment of metal-organic frameworks with polyphenol-mediated stabilized mineralized precursor solution. We then detail their use as templates to assemble metal-phenolic frameworks (MPFs) with mineralized layers. Furthermore, we demonstrate the therapeutic benefits of MPF delivery by hydrogel to the full-thickness skin defect model in rats. For complete details on the use and execution of this protocol, please refer to Zhan et al. (2022).(1)
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spelling pubmed-99850212023-03-05 Protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization for wound healing in rats Zhan, Xiaolong Wen, Zhengbo Chen, Yuxin Feng, Jiaxin Liang, Ke Xue, Liecong He, Peiying Chen, Honglin Zhu, Wei STAR Protoc Protocol Here, we present a protocol for controllable biomimetic mineralization at the nano-scale, simulating natural ion-enriched sedimentary mineralization. We describe steps for treatment of metal-organic frameworks with polyphenol-mediated stabilized mineralized precursor solution. We then detail their use as templates to assemble metal-phenolic frameworks (MPFs) with mineralized layers. Furthermore, we demonstrate the therapeutic benefits of MPF delivery by hydrogel to the full-thickness skin defect model in rats. For complete details on the use and execution of this protocol, please refer to Zhan et al. (2022).(1) Elsevier 2023-02-25 /pmc/articles/PMC9985021/ /pubmed/36861839 http://dx.doi.org/10.1016/j.xpro.2023.102131 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Protocol
Zhan, Xiaolong
Wen, Zhengbo
Chen, Yuxin
Feng, Jiaxin
Liang, Ke
Xue, Liecong
He, Peiying
Chen, Honglin
Zhu, Wei
Protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization for wound healing in rats
title Protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization for wound healing in rats
title_full Protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization for wound healing in rats
title_fullStr Protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization for wound healing in rats
title_full_unstemmed Protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization for wound healing in rats
title_short Protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization for wound healing in rats
title_sort protocol to assemble metal-phenolic framework nanoparticles based on polyphenol-mediated biomimetic mineralization for wound healing in rats
topic Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985021/
https://www.ncbi.nlm.nih.gov/pubmed/36861839
http://dx.doi.org/10.1016/j.xpro.2023.102131
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