NLRP12-expressing dendritic cells mediate both dissemination of infection and adaptive immune responses in visceral leishmaniasis

The NLR protein NLRP12 contributes to innate immunity, but the mechanism remains elusive. Infection of Nlrp12(−/−) or wild-type mice with Leishmania infantum led to aberrant parasite tropism. Parasites replicated to higher levels in livers of Nlrp12(−/−) mice than in the livers of WT mice and failed...

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Autores principales: Valadares, Diogo Garcia, Clay, Owen Scott, Chen, Yani, Scorza, Breanna Mary, Cassel, Suzanne Louise, Sutterwala, Fayyaz Shiraz, Wilson, Mary Edythe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985045/
https://www.ncbi.nlm.nih.gov/pubmed/36879824
http://dx.doi.org/10.1016/j.isci.2023.106163

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