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A fully human connective tissue growth factor blocking monoclonal antibody ameliorates experimental rheumatoid arthritis through inhibiting angiogenesis

BACKGROUND: Connective tissue growth factor (CTGF) plays a pivotal role in the pathogenesis of rheumatoid arthritis (RA) by facilitating angiogenesis and is a promising therapeutic target for RA treatment. Herein, we generated a fully human CTGF blocking monoclonal antibody (mAb) through phage displ...

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Detalles Bibliográficos
Autores principales:	Qin, Yang, Wu, Gan, Jin, Jiayi, Wang, Hao, Zhang, Jiani, Liu, Li, Zhao, Heping, Wang, Jianguang, Yang, Xinyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985226/ https://www.ncbi.nlm.nih.gov/pubmed/36869335 http://dx.doi.org/10.1186/s12896-023-00776-8

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