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Multiomics analysis revealed the mechanisms related to the enhancement of proliferation, metastasis and EGFR-TKI resistance in EGFR-mutant LUAD with ARID1A deficiency

INTRODUCTION: Dysregulated ARID1A expression is frequently detected in lung adenocarcinoma (LUAD) and mediates significant changes in cancer behaviors and a poor prognosis. ARID1A deficiency in LUAD enhances proliferation and metastasis, which could be induced by activation of the Akt signaling path...

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Detalles Bibliográficos
Autores principales:	Sun, Dantong, Feng, Feiyue, Teng, Fei, Xie, Tongji, Wang, Jinsong, Xing, Puyuan, Qian, Haili, Li, Junling
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985251/ https://www.ncbi.nlm.nih.gov/pubmed/36869329 http://dx.doi.org/10.1186/s12964-023-01065-9

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