Induction of DNMT1-dependent demethylation of SHP-1 by the natural flavonoid compound Baicalein overcame Imatinib-resistance in CML CD34(+) cells

BACKGROUND: The most significant cause of treatment failure in chronic myeloid leukemia (CML) is a persistent population of minimal residual cells. Emerging evidences showed that methylation of SHP-1 contributed to Imatinib (IM) resistance. Baicalein was reported to have an effect on reversal of che...

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Detalles Bibliográficos
Autores principales: Xu, Xuefen, Ji, Shufan, Chen, Yuan, Xia, Siwei, Li, Yang, Chen, Li, Li, Yujia, Zhang, Feng, Zhang, Zili, Zheng, Shizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985268/
https://www.ncbi.nlm.nih.gov/pubmed/36869331
http://dx.doi.org/10.1186/s12964-023-01049-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985268/
https://www.ncbi.nlm.nih.gov/pubmed/36869331
http://dx.doi.org/10.1186/s12964-023-01049-9

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