Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but aggressive malignancy with high mortality involving the skin and hematopoietic system. Clinical suspicion is difficult, and management of skin lesions is challenging due to their indolent course prior to dissemination. We describe a...

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Detalles Bibliográficos
Autores principales: Suárez, Amaranto, Soler, Nathalie, Calderon, Alejandra, Martinez, Bibiana, Piña, Martha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Pediatrics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985430/
https://www.ncbi.nlm.nih.gov/pubmed/36879711
http://dx.doi.org/10.7759/cureus.34549
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author Suárez, Amaranto
Soler, Nathalie
Calderon, Alejandra
Martinez, Bibiana
Piña, Martha
author_facet Suárez, Amaranto
Soler, Nathalie
Calderon, Alejandra
Martinez, Bibiana
Piña, Martha
author_sort Suárez, Amaranto
collection PubMed
description Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but aggressive malignancy with high mortality involving the skin and hematopoietic system. Clinical suspicion is difficult, and management of skin lesions is challenging due to their indolent course prior to dissemination. We describe a patient with isolated skin involvement who progressed to CD4+/CD56+ and CD123+ acute leukemia.
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spelling pubmed-99854302023-03-05 Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report Suárez, Amaranto Soler, Nathalie Calderon, Alejandra Martinez, Bibiana Piña, Martha Cureus Pediatrics Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare but aggressive malignancy with high mortality involving the skin and hematopoietic system. Clinical suspicion is difficult, and management of skin lesions is challenging due to their indolent course prior to dissemination. We describe a patient with isolated skin involvement who progressed to CD4+/CD56+ and CD123+ acute leukemia. Cureus 2023-02-02 /pmc/articles/PMC9985430/ /pubmed/36879711 http://dx.doi.org/10.7759/cureus.34549 Text en Copyright © 2023, Suárez et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pediatrics
Suárez, Amaranto
Soler, Nathalie
Calderon, Alejandra
Martinez, Bibiana
Piña, Martha
Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report
title Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report
title_full Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report
title_fullStr Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report
title_full_unstemmed Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report
title_short Pediatric Blastic Plasmacytoid Dendritic Cell Neoplasm, Clinical Features and Immunophenotype: A Case Report
title_sort pediatric blastic plasmacytoid dendritic cell neoplasm, clinical features and immunophenotype: a case report
topic Pediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985430/
https://www.ncbi.nlm.nih.gov/pubmed/36879711
http://dx.doi.org/10.7759/cureus.34549
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