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Sympathetic neurons secrete retrogradely transported TrkA on extracellular vesicles

Proper wiring of the peripheral nervous system relies on neurotrophic signaling via nerve growth factor (NGF). NGF secreted by target organs (i.e. eye) binds to the TrkA receptor expressed on the distal axons of postganglionic neurons. Upon binding, TrkA is internalized into a signaling endosome and...

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Detalles Bibliográficos
Autores principales:	Mason, Ashley J., Keeler, Austin B., Kabir, Farah, Winckler, Bettina, Deppmann, Christopher
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985603/ https://www.ncbi.nlm.nih.gov/pubmed/36871060 http://dx.doi.org/10.1038/s41598-023-30728-3

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