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Standard of care drugs do not modulate activity of senescent primary human lung fibroblasts

Cellular senescence is crucial in the progression of idiopathic pulmonary fibrosis (IPF), but it is not evident whether the standard-of-care (SOC) drugs, nintedanib and pirfenidone, have senolytic properties. To address this question, we performed colorimetric and fluorimetric assays, qRT-PCR, and w...

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Detalles Bibliográficos
Autores principales:	Badaro-Garcia, Stephanie, Hohmann, Miriam S., Coelho, Ana Lucia, Verri, Waldiceu A., Hogaboam, Cory M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985617/ https://www.ncbi.nlm.nih.gov/pubmed/36871123 http://dx.doi.org/10.1038/s41598-023-30844-0

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