Cargando…

CDK4/6 inhibition triggers ICAM1-driven immune response and sensitizes LKB1 mutant lung cancer to immunotherapy

Liver kinase B1 (LKB1) mutation is prevalent and a driver of resistance to immune checkpoint blockade (ICB) therapy for lung adenocarcinoma. Here leveraging single cell RNA sequencing data, we demonstrate that trafficking and adhesion process of activated T cells are defected in genetically engineer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bai, Xue, Guo, Ze-Qin, Zhang, Yan-Pei, Fan, Zhen-zhen, Liu, Li-Juan, Liu, Li, Long, Li-Li, Ma, Si-Cong, Wang, Jian, Fang, Yuan, Tang, Xin-Ran, Zeng, Yu-Jie, Pan, Xinghua, Wu, De-Hua, Dong, Zhong-Yi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985635/ https://www.ncbi.nlm.nih.gov/pubmed/36871040 http://dx.doi.org/10.1038/s41467-023-36892-4

Ejemplares similares

Expression profiling of ubiquitin-related genes in LKB1 mutant lung adenocarcinoma
por: Wang, Guanghui, et al.
Publicado: (2018)

Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
por: Just, Pierre-Alexandre, et al.
Publicado: (2020)

A subset of VEGFR‐TKIs activates AMPK in LKB1‐mutant lung cancer
por: Yang, Lujie, et al.
Publicado: (2022)

LKB1 suppression promotes cardiomyocyte regeneration via LKB1-AMPK-YAP axis
por: Qu, Shuang, et al.
Publicado: (2022)

Glucocorticoid mediated inhibition of LKB1 mutant non-small cell lung cancers
por: Huffman, Kenneth E., et al.
Publicado: (2023)

TWEAK Enhances E-selectin and ICAM-1 Expression, and May Contribute to the Development of Cutaneous Vasculitis
por: Chen, Tao, et al.
Publicado: (2013)

Inhibition of β-Catenin Activity Abolishes LKB1 Loss-Driven Pancreatic Cystadenoma in Mice
por: Hsieh, Mei-Jen, et al.
Publicado: (2021)

The hexosamine biosynthesis pathway is a targetable liability in KRAS/LKB1-mutant lung cancer
por: Kim, Jiyeon, et al.
Publicado: (2020)

Author Correction: Lkb1 suppresses amino acid-driven gluconeogenesis in the liver
por: Just, Pierre-Alexandre, et al.
Publicado: (2021)

ULK1 inhibition overcomes compromised antigen presentation and restores antitumor immunity in LKB1 mutant lung cancer
por: Deng, Jiehui, et al.
Publicado: (2021)

LKB1 tumor suppressor: Therapeutic opportunities knock when LKB1 is inactivated
por: Zhou, Wei, et al.
Publicado: (2014)

The level of oncogenic Ras determines the malignant transformation of Lkb1 mutant tissue in vivo
por: Rackley, Briana, et al.
Publicado: (2021)

CPS1 maintains pyrimidine pools and DNA synthesis in KRAS/LKB1-mutant lung cancer cells
por: Kim, Jiyeon, et al.
Publicado: (2017)

Kiss1 Inhibits the Proliferation of Nasopharyngeal Carcinoma Cells Via Activation of the LKB1/AMPK Pathway
por: Li, Tingting, et al.
Publicado: (2022)

Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling
por: Li, Nan, et al.
Publicado: (2019)

Molecular Characterization of LKB1 of Triploid Crucian Carp and Its Regulation on Muscle Growth and Quality
por: Zuo, Anli, et al.
Publicado: (2022)

LKB1 pro‐oncogenic activity triggers cell survival in circulating tumor cells
por: Trapp, Elisabeth Katharina, et al.
Publicado: (2017)

The Prognostic Model and Drug Sensitivity of LKB1-Mutant Lung Adenocarcinoma Based on Immune Landscape
por: Wang, Guanghui, et al.
Publicado: (2022)

Resveratrol-induced Sirt1 phosphorylation by LKB1 mediates mitochondrial metabolism
por: Huang, Yuanyuan, et al.
Publicado: (2021)

LKB1 Regulates Vascular Macrophage Functions in Atherosclerosis
por: Wang, Xuewen, et al.
Publicado: (2021)

AXL targeting restores PD-1 blockade sensitivity of STK11/LKB1 mutant NSCLC through expansion of TCF1(+) CD8 T cells
por: Li, Huiyu, et al.
Publicado: (2022)

The magnitude of LFA-1/ICAM-1 forces fine-tune TCR-triggered T cell activation
por: Ma, Victor Pui-Yan, et al.
Publicado: (2022)

ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo
por: Chong, Deborah L. W., et al.
Publicado: (2021)

Overexpressed DEPDC1B contributes to the progression of hepatocellular carcinoma by CDK1
por: Dang, Xiao-Wei, et al.
Publicado: (2021)

G6PD Maintains Redox Homeostasis and Biosynthesis in LKB1-Deficient KRAS-Driven Lung Cancer
por: Lan, Taijin, et al.
Publicado: (2023)

Inhibition of autophagy and MEK promotes ferroptosis in Lkb1-deficient Kras-driven lung tumors
por: Bhatt, Vrushank, et al.
Publicado: (2023)

LKB1 as the ghostwriter of crypt history
por: Jansen, Marnix, et al.
Publicado: (2011)

AMPK potentiation by LKB1 isoforms
por: Thibert, Chantal, et al.
Publicado: (2015)

LKB1 in transmembrane receptor signaling
por: Okon, Imoh S., et al.
Publicado: (2015)

Characterization of the function of intercellular adhesion molecule (ICAM)-3 and comparison with ICAM-1 and ICAM-2 in immune responses
Publicado: (1994)

ICAM-1 controls development and function of ILC2
por: Lei, Ai-Hua, et al.
Publicado: (2018)

STK11 (LKB1) missense somatic mutant isoforms promote tumor growth, motility and inflammation
por: Granado-Martínez, Paula, et al.
Publicado: (2020)

ICAM-3 interacts with LFA-1 and regulates the LFA-1/ICAM-1 cell adhesion pathway
Publicado: (1993)

Potentiality of α-fetoprotein (AFP) and soluble intercellular adhesion molecule-1 (sICAM-1) in prognosis prediction and immunotherapy response for patients with hepatocellular carcinoma
por: Cao, Weiwei, et al.
Publicado: (2021)

O1.5. ICAM-1 IS INCREASED IN BRAIN AND PERIPHERAL LEVELS OF SOLUBLE ICAM-1 IS RELATED TO COGNITIVE DEFICITS IN SCHIZOPHRENIA
por: Weickert, Thomas, et al.
Publicado: (2018)

Involvement of the "I" domain of LFA-1 in selective binding to ligands ICAM-1 and ICAM-3
Publicado: (1994)

ICAM‐1‐targeted nanocarriers attenuate endothelial release of soluble ICAM‐1, an inflammatory regulator
por: Manthe, Rachel L., et al.
Publicado: (2017)

Lkb1 maintains T(reg) cell lineage identity
por: Wu, Di, et al.
Publicado: (2017)

Decreased LKB1 predicts poor prognosis in Pancreatic Ductal Adenocarcinoma
por: Yang, Jian-Yu, et al.
Publicado: (2015)

LKB1 regulates quiescence and metabolic homeostasis of hematopoietic stem cells
por: Gan, Boyi, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_83fel6tcohueohst20o3vjacco