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The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?

Autophagy plays a critical role in balancing sources of energy in response to harsh conditions and nutrient deprivation. Autophagy allows cells to survive in harsh condition and also serve as a death mechanism. Any dysregulation in autophagy signaling may lead to several disorders. Autophagy has bee...

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Autores principales: Haghi, Atousa, Mohammadi Kian, Mahnaz, Salemi, Mahdieh, Eghdami, Mohammad Reza, Nikbakht, Mohsen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985813/
https://www.ncbi.nlm.nih.gov/pubmed/36883106
http://dx.doi.org/10.18502/ijhoscr.v16i4.10883
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author Haghi, Atousa
Mohammadi Kian, Mahnaz
Salemi, Mahdieh
Eghdami, Mohammad Reza
Nikbakht, Mohsen
author_facet Haghi, Atousa
Mohammadi Kian, Mahnaz
Salemi, Mahdieh
Eghdami, Mohammad Reza
Nikbakht, Mohsen
author_sort Haghi, Atousa
collection PubMed
description Autophagy plays a critical role in balancing sources of energy in response to harsh conditions and nutrient deprivation. Autophagy allows cells to survive in harsh condition and also serve as a death mechanism. Any dysregulation in autophagy signaling may lead to several disorders. Autophagy has been proposed to explain chemotherapy resistance in acute myeloid leukemia (AML). This signaling pathway can either act as a tumor suppressive function or chemo-resistance mechanism. Conventional chemotherapy drugs enhance apoptosis and indicate clinical benefit, but in some cases, relapse and chemotherapy resistance are observed. In leukemia, autophagy may promote cell survival in response to chemotherapy drugs. Therefore, new strategies by inhibiting or activating autophagy may find a broad application for treating leukemia and may significantly enhance clinical outcomes. In this review, we discussed the dimensional role of autophagy in leukemia. 
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spelling pubmed-99858132023-03-06 The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)? Haghi, Atousa Mohammadi Kian, Mahnaz Salemi, Mahdieh Eghdami, Mohammad Reza Nikbakht, Mohsen Int J Hematol Oncol Stem Cell Res Review Article Autophagy plays a critical role in balancing sources of energy in response to harsh conditions and nutrient deprivation. Autophagy allows cells to survive in harsh condition and also serve as a death mechanism. Any dysregulation in autophagy signaling may lead to several disorders. Autophagy has been proposed to explain chemotherapy resistance in acute myeloid leukemia (AML). This signaling pathway can either act as a tumor suppressive function or chemo-resistance mechanism. Conventional chemotherapy drugs enhance apoptosis and indicate clinical benefit, but in some cases, relapse and chemotherapy resistance are observed. In leukemia, autophagy may promote cell survival in response to chemotherapy drugs. Therefore, new strategies by inhibiting or activating autophagy may find a broad application for treating leukemia and may significantly enhance clinical outcomes. In this review, we discussed the dimensional role of autophagy in leukemia.  Tehran University of Medical Sciences, Hematology-Oncology and Stem Cell Transplantation Research Center 2022-10-01 /pmc/articles/PMC9985813/ /pubmed/36883106 http://dx.doi.org/10.18502/ijhoscr.v16i4.10883 Text en Copyright © 2022 Tehran University of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International license (https://creativecommons.org/licenses/by-nc/4.0/). Non-commercial uses of the work are permitted, provided the original work is properly cited.
spellingShingle Review Article
Haghi, Atousa
Mohammadi Kian, Mahnaz
Salemi, Mahdieh
Eghdami, Mohammad Reza
Nikbakht, Mohsen
The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?
title The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?
title_full The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?
title_fullStr The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?
title_full_unstemmed The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?
title_short The Question of Survival or Death: What Is the Role of Autophagy in Acute Myeloid Leukemia (AML)?
title_sort question of survival or death: what is the role of autophagy in acute myeloid leukemia (aml)?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985813/
https://www.ncbi.nlm.nih.gov/pubmed/36883106
http://dx.doi.org/10.18502/ijhoscr.v16i4.10883
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