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Heart in a dish – choosing the right in vitro model
The heart is the first functional organ established during embryogenesis. Investigating heart development and disease is a fascinating and crucial field of research because cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Therefore, there is great interest in es...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Company of Biologists Ltd
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985945/ https://www.ncbi.nlm.nih.gov/pubmed/36825553 http://dx.doi.org/10.1242/dmm.049961 |
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author | Drakhlis, Lika Zweigerdt, Robert |
author_facet | Drakhlis, Lika Zweigerdt, Robert |
author_sort | Drakhlis, Lika |
collection | PubMed |
description | The heart is the first functional organ established during embryogenesis. Investigating heart development and disease is a fascinating and crucial field of research because cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Therefore, there is great interest in establishing in vitro models for recapitulating both physiological and pathological aspects of human heart development, tissue function and malfunction. Derived from pluripotent stem cells, a large variety of three-dimensional cardiac in vitro models have been introduced in recent years. In this At a Glance article, we discuss the available methods to generate such models, grouped according to the following classification: cardiac organoids, cardiac microtissues and engineered cardiac tissues. For these models, we provide a systematic overview of their applications for disease modeling and therapeutic development, as well as their advantages and limitations to assist scientists in choosing the most suitable model for their research purpose. |
format | Online Article Text |
id | pubmed-9985945 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | The Company of Biologists Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-99859452023-03-06 Heart in a dish – choosing the right in vitro model Drakhlis, Lika Zweigerdt, Robert Dis Model Mech At A Glance The heart is the first functional organ established during embryogenesis. Investigating heart development and disease is a fascinating and crucial field of research because cardiovascular diseases remain the leading cause of morbidity and mortality worldwide. Therefore, there is great interest in establishing in vitro models for recapitulating both physiological and pathological aspects of human heart development, tissue function and malfunction. Derived from pluripotent stem cells, a large variety of three-dimensional cardiac in vitro models have been introduced in recent years. In this At a Glance article, we discuss the available methods to generate such models, grouped according to the following classification: cardiac organoids, cardiac microtissues and engineered cardiac tissues. For these models, we provide a systematic overview of their applications for disease modeling and therapeutic development, as well as their advantages and limitations to assist scientists in choosing the most suitable model for their research purpose. The Company of Biologists Ltd 2023-02-24 /pmc/articles/PMC9985945/ /pubmed/36825553 http://dx.doi.org/10.1242/dmm.049961 Text en © 2023. Published by The Company of Biologists Ltd https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. |
spellingShingle | At A Glance Drakhlis, Lika Zweigerdt, Robert Heart in a dish – choosing the right in vitro model |
title | Heart in a dish – choosing the right in vitro model |
title_full | Heart in a dish – choosing the right in vitro model |
title_fullStr | Heart in a dish – choosing the right in vitro model |
title_full_unstemmed | Heart in a dish – choosing the right in vitro model |
title_short | Heart in a dish – choosing the right in vitro model |
title_sort | heart in a dish – choosing the right in vitro model |
topic | At A Glance |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9985945/ https://www.ncbi.nlm.nih.gov/pubmed/36825553 http://dx.doi.org/10.1242/dmm.049961 |
work_keys_str_mv | AT drakhlislika heartinadishchoosingtherightinvitromodel AT zweigerdtrobert heartinadishchoosingtherightinvitromodel |