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Impact of age on in vitro metabolism of clopidogrel: a potential explanation for high on-treatment platelet reactivity in the elderly?

BACKGROUND: High on-treatment platelet reactivity has been reported in 30% of patients on clopidogrel and 50% in elderly patients; however, little is known about the mechanisms of this biological resistance. One hypothesis is an age-related impaired hepatic metabolism of the prodrug clopidogrel, lea...

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Detalles Bibliográficos
Autores principales:	Pontis, Adeline, Delavenne, Xavier, Verdier, Marie-Clémence, Hodin, Sophie, Andriamaharo, Annie, Gueret, Pierre, Nedelec-Gac, Fabienne, Bachelot-Loza, Christilla, Gaussem, Pascale, Gouin-Thibault, Isabelle
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Brief Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986101/ https://www.ncbi.nlm.nih.gov/pubmed/36891520 http://dx.doi.org/10.1016/j.rpth.2022.100014

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