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The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes”
A role for COVID19 in “hyperferritinemic syndromes” has been proposed based on its clinical and serological characteristics and its similarities with AOSD. To better understand the molecular pathways responsible of these similarities, we evaluated in the PBMCs of 4 active AOSD patients, 2 COVID19 pa...
| Autores principales: | , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Elsevier B.V.
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986116/ https://www.ncbi.nlm.nih.gov/pubmed/36889656 http://dx.doi.org/10.1016/j.autrev.2023.103309 |
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| author | Berardicurti, Onorina Navarini, Luca Vomero, Marta Currado, Damiano Biaggi, Alice Marino, Annalisa Bearzi, Pietro Corberi, Erika Rigon, Amelia Arcarese, Luisa Vadacca, Marta Mattei, Alessia Agrò, Felice Eugenio Incalzi, Raffaele Antonelli Sambuco, Federica Travaglino, Francesco Ruscitti, Piero Cipriani, Paola Giacomelli, Roberto |
| author_facet | Berardicurti, Onorina Navarini, Luca Vomero, Marta Currado, Damiano Biaggi, Alice Marino, Annalisa Bearzi, Pietro Corberi, Erika Rigon, Amelia Arcarese, Luisa Vadacca, Marta Mattei, Alessia Agrò, Felice Eugenio Incalzi, Raffaele Antonelli Sambuco, Federica Travaglino, Francesco Ruscitti, Piero Cipriani, Paola Giacomelli, Roberto |
| author_sort | Berardicurti, Onorina |
| collection | PubMed |
| description | A role for COVID19 in “hyperferritinemic syndromes” has been proposed based on its clinical and serological characteristics and its similarities with AOSD. To better understand the molecular pathways responsible of these similarities, we evaluated in the PBMCs of 4 active AOSD patients, 2 COVID19 patients with ARDS, and 2 HCs the expression of genes associated with iron metabolisms, with monocyte/macrophages activation, and finally with NETs formation. |
| format | Online Article Text |
| id | pubmed-9986116 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2023 |
| publisher | Elsevier B.V. |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-99861162023-03-06 The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes” Berardicurti, Onorina Navarini, Luca Vomero, Marta Currado, Damiano Biaggi, Alice Marino, Annalisa Bearzi, Pietro Corberi, Erika Rigon, Amelia Arcarese, Luisa Vadacca, Marta Mattei, Alessia Agrò, Felice Eugenio Incalzi, Raffaele Antonelli Sambuco, Federica Travaglino, Francesco Ruscitti, Piero Cipriani, Paola Giacomelli, Roberto Autoimmun Rev Article A role for COVID19 in “hyperferritinemic syndromes” has been proposed based on its clinical and serological characteristics and its similarities with AOSD. To better understand the molecular pathways responsible of these similarities, we evaluated in the PBMCs of 4 active AOSD patients, 2 COVID19 patients with ARDS, and 2 HCs the expression of genes associated with iron metabolisms, with monocyte/macrophages activation, and finally with NETs formation. Elsevier B.V. 2023-05 2023-03-06 /pmc/articles/PMC9986116/ /pubmed/36889656 http://dx.doi.org/10.1016/j.autrev.2023.103309 Text en © 2023 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| spellingShingle | Article Berardicurti, Onorina Navarini, Luca Vomero, Marta Currado, Damiano Biaggi, Alice Marino, Annalisa Bearzi, Pietro Corberi, Erika Rigon, Amelia Arcarese, Luisa Vadacca, Marta Mattei, Alessia Agrò, Felice Eugenio Incalzi, Raffaele Antonelli Sambuco, Federica Travaglino, Francesco Ruscitti, Piero Cipriani, Paola Giacomelli, Roberto The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes” |
| title | The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes” |
| title_full | The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes” |
| title_fullStr | The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes” |
| title_full_unstemmed | The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes” |
| title_short | The similar expression of both ferritin and scavenger receptors activation genes in patients with COVID19 and AOSD support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes” |
| title_sort | similar expression of both ferritin and scavenger receptors activation genes in patients with covid19 and aosd support their role in the pathogenesis of these diseases and identify a common mechanism at the basis of the “hyperferritinemic syndromes” |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986116/ https://www.ncbi.nlm.nih.gov/pubmed/36889656 http://dx.doi.org/10.1016/j.autrev.2023.103309 |
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similarexpressionofbothferritinandscavengerreceptorsactivationgenesinpatientswithcovid19andaosdsupporttheirroleinthepathogenesisofthesediseasesandidentifyacommonmechanismatthebasisofthehyperferritinemicsyndromes AT giacomelliroberto similarexpressionofbothferritinandscavengerreceptorsactivationgenesinpatientswithcovid19andaosdsupporttheirroleinthepathogenesisofthesediseasesandidentifyacommonmechanismatthebasisofthehyperferritinemicsyndromes |