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Toward a global virus genomic surveillance network
The COVID-19 pandemic galvanized the field of virus genomic surveillance, demonstrating its utility for public health. Now, we must harness the momentum that led to increased infrastructure, training, and political will to build a sustainable global genomic surveillance network for other epidemic an...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Inc.
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986120/ https://www.ncbi.nlm.nih.gov/pubmed/36921604 http://dx.doi.org/10.1016/j.chom.2023.03.003 |
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author | Hill, Verity Githinji, George Vogels, Chantal B.F. Bento, Ana I. Chaguza, Chrispin Carrington, Christine V.F. Grubaugh, Nathan D. |
author_facet | Hill, Verity Githinji, George Vogels, Chantal B.F. Bento, Ana I. Chaguza, Chrispin Carrington, Christine V.F. Grubaugh, Nathan D. |
author_sort | Hill, Verity |
collection | PubMed |
description | The COVID-19 pandemic galvanized the field of virus genomic surveillance, demonstrating its utility for public health. Now, we must harness the momentum that led to increased infrastructure, training, and political will to build a sustainable global genomic surveillance network for other epidemic and endemic viruses. We suggest a generalizable modular sequencing framework wherein users can easily switch between virus targets to maximize cost-effectiveness and maintain readiness for new threats. We also highlight challenges associated with genomic surveillance and when global inequalities persist. We propose solutions to mitigate some of these issues, including training and multilateral partnerships. Exploring alternatives to clinical sequencing can also reduce the cost of surveillance programs. Finally, we discuss how establishing genomic surveillance would aid control programs and potentially provide a warning system for outbreaks, using a global respiratory virus (RSV), an arbovirus (dengue virus), and a regional zoonotic virus (Lassa virus) as examples. |
format | Online Article Text |
id | pubmed-9986120 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-99861202023-03-06 Toward a global virus genomic surveillance network Hill, Verity Githinji, George Vogels, Chantal B.F. Bento, Ana I. Chaguza, Chrispin Carrington, Christine V.F. Grubaugh, Nathan D. Cell Host Microbe Perspective The COVID-19 pandemic galvanized the field of virus genomic surveillance, demonstrating its utility for public health. Now, we must harness the momentum that led to increased infrastructure, training, and political will to build a sustainable global genomic surveillance network for other epidemic and endemic viruses. We suggest a generalizable modular sequencing framework wherein users can easily switch between virus targets to maximize cost-effectiveness and maintain readiness for new threats. We also highlight challenges associated with genomic surveillance and when global inequalities persist. We propose solutions to mitigate some of these issues, including training and multilateral partnerships. Exploring alternatives to clinical sequencing can also reduce the cost of surveillance programs. Finally, we discuss how establishing genomic surveillance would aid control programs and potentially provide a warning system for outbreaks, using a global respiratory virus (RSV), an arbovirus (dengue virus), and a regional zoonotic virus (Lassa virus) as examples. Elsevier Inc. 2023-06-14 2023-03-06 /pmc/articles/PMC9986120/ /pubmed/36921604 http://dx.doi.org/10.1016/j.chom.2023.03.003 Text en © 2023 Elsevier Inc. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Perspective Hill, Verity Githinji, George Vogels, Chantal B.F. Bento, Ana I. Chaguza, Chrispin Carrington, Christine V.F. Grubaugh, Nathan D. Toward a global virus genomic surveillance network |
title | Toward a global virus genomic surveillance network |
title_full | Toward a global virus genomic surveillance network |
title_fullStr | Toward a global virus genomic surveillance network |
title_full_unstemmed | Toward a global virus genomic surveillance network |
title_short | Toward a global virus genomic surveillance network |
title_sort | toward a global virus genomic surveillance network |
topic | Perspective |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986120/ https://www.ncbi.nlm.nih.gov/pubmed/36921604 http://dx.doi.org/10.1016/j.chom.2023.03.003 |
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