Cargando…

Design of a stabilized RBD enables potently neutralizing SARS-CoV-2 single-component nanoparticle vaccines

Waning immunity and emerging variants necessitate continued vaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Improvements in vaccine safety, tolerability, and ease of manufacturing would benefit these efforts. Here, we develop a potent and easily manufactured nanopar...

Descripción completa

Detalles Bibliográficos
Autores principales:	Dickey, Thayne H., Ma, Rui, Orr-Gonzalez, Sachy, Ouahes, Tarik, Patel, Palak, McAleese, Holly, Butler, Brandi, Eudy, Elizabeth, Eaton, Brett, Murphy, Michael, Kwan, Jennifer L., Salinas, Nichole D., Holbrook, Michael R., Lambert, Lynn E., Tolia, Niraj H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986124/ https://www.ncbi.nlm.nih.gov/pubmed/36943870 http://dx.doi.org/10.1016/j.celrep.2023.112266

Ejemplares similares

Design of the SARS-CoV-2 RBD vaccine antigen improves neutralizing antibody response
por: Dickey, Thayne H., et al.
Publicado: (2022)

Design of a stabilized non-glycosylated Pfs48/45 antigen enables a potent malaria transmission-blocking nanoparticle vaccine
por: Dickey, Thayne H., et al.
Publicado: (2023)

A potent and durable malaria transmission-blocking vaccine designed from a single-component 60-copy Pfs230D1 nanoparticle
por: Salinas, Nichole D., et al.
Publicado: (2023)

Structure-based design of a strain transcending AMA1-RON2L malaria vaccine
por: Patel, Palak N., et al.
Publicado: (2023)

Protein-protein conjugation enhances the immunogenicity of SARS-CoV-2 receptor-binding domain (RBD) vaccines
por: Scaria, Puthupparampil V., et al.
Publicado: (2022)

Neutralizing and interfering human antibodies define the structural and mechanistic basis for antigenic diversion
por: Patel, Palak N., et al.
Publicado: (2022)

Critical Glycosylated Residues in Exon Three of Erythrocyte Glycophorin A Engage Plasmodium falciparum EBA-175 and Define Receptor Specificity
por: Salinas, Nichole D., et al.
Publicado: (2014)

Structural Analysis of the Synthetic Duffy Binding Protein (DBP) Antigen DEKnull Relevant for Plasmodium vivax Malaria Vaccine Design
por: Chen, Edwin, et al.
Publicado: (2015)

Structural and Functional Basis for Inhibition of Erythrocyte Invasion by Antibodies that Target Plasmodium falciparum EBA-175
por: Chen, Edwin, et al.
Publicado: (2013)

A minimal RNA ligand for potent RIG-I activation in living mice
por: Linehan, Melissa M., et al.
Publicado: (2018)

The telomeric protein Pot1 from Schizosaccharomyces pombe binds ssDNA in two modes with differing 3′ end availability
por: Dickey, Thayne H., et al.
Publicado: (2014)

No evidence of increased susceptibility to COVID-19 virus among radical lung radiotherapy patients
por: Lepiarczyk, Oskar, et al.
Publicado: (2021)

COVID-19 patient serum less potently inhibits ACE2-RBD binding for various SARS-CoV-2 RBD mutants
por: Junker, Daniel, et al.
Publicado: (2022)

Implications of conformational flexibility, lipid binding, and regulatory domains in cell-traversal protein CelTOS for apicomplexan migration
por: Kumar, Hirdesh, et al.
Publicado: (2022)

The SMAD3 transcription factor binds complex RNA structures with high affinity
por: Dickey, Thayne H., et al.
Publicado: (2017)

Shed EBA-175 mediates red blood cell clustering that enhances malaria parasite growth and enables immune evasion
por: Paing, May M, et al.
Publicado: (2018)

An Assessment of Psychological Need in Emergency Medical Staff in the Northern Health and Social Care Trust Area
por: Aisling, McAleese, et al.
Publicado: (2016)

Posteriorly displaced salter halter fracture-dislocation at the sternoclavicular joint with associated thoracic outlet syndrome: A case report
por: McAleese, Timothy, et al.
Publicado: (2020)

Quality and Presence of Behaviour Change Techniques in Mobile Apps for the Mediterranean Diet: A Content Analysis of Android Google Play and Apple App Store Apps
por: McAleese, Daniel, et al.
Publicado: (2022)

Scientific rationale for developing potent RBD-based vaccines targeting COVID-19
por: Kleanthous, Harry, et al.
Publicado: (2021)

Does lucency equate to revision? A five-year retrospective review of Attune and Triathlon total knee arthroplasty
por: O’Donovan, Paul, et al.
Publicado: (2023)

Neuroendocrine carcinoma arising in soft tissue: three case reports and literature review
por: Hyer, Steve L, et al.
Publicado: (2007)

‘Emigration is a matter of self-preservation. The working conditions . . . are killing us slowly’: qualitative insights into health professional emigration from Ireland
por: Humphries, Niamh, et al.
Publicado: (2015)

Thyroid radiation shields: A potential source of intraoperative infection
por: McAleese, T., et al.
Publicado: (2020)

Cationic nanocarriers as potent adjuvants for recombinant S-RBD vaccine of SARS-CoV-2
por: Lei, Hong, et al.
Publicado: (2020)

Malaria parasite CelTOS targets the inner leaflet of cell membranes for pore-dependent disruption
por: Jimah, John R, et al.
Publicado: (2016)

Data on elemental concentrations in marine sediments from the South and South West of England
por: Richir, Jonathan, et al.
Publicado: (2021)

Bilateral patellar tendon rupture following low-energy trauma in a young patient without predisposing risk factors
por: Murphy, Suzanne M., et al.
Publicado: (2022)

Arylamine N-acetyltransferase 1 deficiency inhibits drug-induced cell death in breast cancer cells: switch from cytochrome C-dependent apoptosis to necroptosis
por: McAleese, Courtney E., et al.
Publicado: (2022)

Getting in: The structural biology of malaria invasion
por: Kumar, Hirdesh, et al.
Publicado: (2019)

Protein-based antigen presentation platforms for nanoparticle vaccines
por: Nguyen, Brian, et al.
Publicado: (2021)

Gone for good? An online survey of emigrant health professionals using Facebook as a recruitment tool
por: McAleese, Sara, et al.
Publicado: (2016)

Potent neutralizing RBD‐specific antibody cocktail against SARS‐CoV‐2 and its mutant
por: Jia, Lina, et al.
Publicado: (2021)

Multimeric Assembly of Host-Pathogen Adhesion Complexes Involved in Apicomplexan Invasion
por: Paing, May M., et al.
Publicado: (2014)

The consequences of Ireland’s culture of medical migration
por: Humphries, Niamh, et al.
Publicado: (2017)

Kocuria rhizophila prosthetic hip joint infection
por: McAleese, Timothy, et al.
Publicado: (2023)

Recurrent chondroblastoma of the talus: A case report and literature review of recurrent lesions in the foot and ankle
por: Jagiella-Lodise, Olivia, et al.
Publicado: (2023)

Structural basis for neutralization of P. vivax by naturally-acquired human antibodies that target DBP
por: Urusova, Darya, et al.
Publicado: (2019)

Chloroquine neither eliminates liver stage parasites nor delays their development in a murine Chemoprophylaxis Vaccination model
por: Sahu, Tejram, et al.
Publicado: (2015)

Immunoglobulin fragment F(ab’)(2) against RBD potently neutralizes SARS-CoV-2 in vitro
por: Pan, Xiaoyan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_qjt1e3jmlqdq4kmgr39jvgv26g