Mice deficient in synaptic protease neurotrypsin show impaired spaced long-term potentiation and blunted learning-induced modulation of dendritic spines

Neurotrypsin (NT) is a neuronal trypsin-like serine protease whose mutations cause severe mental retardation in humans. NT is activated in vitro by Hebbian-like conjunction of pre- and postsynaptic activities, which promotes the formation of dendritic filopodia via proteolytic cleavage of the proteo...

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Detalles Bibliográficos
Autores principales: Ferrer-Ferrer, Maura, Jia, Shaobo, Kaushik, Rahul, Schneeberg, Jenny, Figiel, Izabela, Aleshin, Stepan, Mironov, Andrey, Safari, Motahareh, Frischknecht, Renato, Wlodarczyk, Jakub, Senkov, Oleg, Dityatev, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986217/
https://www.ncbi.nlm.nih.gov/pubmed/36871239
http://dx.doi.org/10.1007/s00018-023-04720-z

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