Erianin suppresses constitutive activation of MAPK signaling pathway by inhibition of CRAF and MEK1/2

Constitutive activation of RAS-RAF-MEK-ERK signaling pathway (MAPK pathway) frequently occurs in many cancers harboring RAS or RAF oncogenic mutations. Because of the paradoxical activation induced by a single use of BRAF or MEK inhibitors, dual-target RAF and MEK treatment is thought to be a promis...

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Detalles Bibliográficos
Autores principales: Wang, Penglei, Jia, Xuechao, Lu, Bingbing, Huang, Han, Liu, Jialin, Liu, Xuejiao, Wu, Qiong, Hu, Yamei, Li, Pan, Wei, Huifang, Liu, Tingting, Zhao, Dengyun, Zhang, Lingwei, Tian, Xueli, Jiang, Yanan, Qiao, Yan, Nie, Wenna, Ma, Xinli, Bai, Ruihua, Peng, Cong, Dong, Zigang, Liu, Kangdong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986241/
https://www.ncbi.nlm.nih.gov/pubmed/36872366
http://dx.doi.org/10.1038/s41392-023-01329-3

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