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Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology
Gene regulatory networks are now at the forefront of precision biology, which can help researchers better understand how genes and regulatory elements interact to control cellular gene expression, offering a more promising molecular mechanism in biological research. Interactions between the genes an...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Research Network of Computational and Structural Biotechnology
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986247/ https://www.ncbi.nlm.nih.gov/pubmed/36890880 http://dx.doi.org/10.1016/j.csbj.2023.02.028 |
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author | Zhu, Xiusheng Huang, Qitong Luo, Jing Kong, Dashuai Zhang, Yubo |
author_facet | Zhu, Xiusheng Huang, Qitong Luo, Jing Kong, Dashuai Zhang, Yubo |
author_sort | Zhu, Xiusheng |
collection | PubMed |
description | Gene regulatory networks are now at the forefront of precision biology, which can help researchers better understand how genes and regulatory elements interact to control cellular gene expression, offering a more promising molecular mechanism in biological research. Interactions between the genes and regulatory elements involve different promoters, enhancers, transcription factors, silencers, insulators, and long-range regulatory elements, which occur at a ∼10 µm nucleus in a spatiotemporal manner. In this way, three-dimensional chromatin conformation and structural biology are critical for interpreting the biological effects and the gene regulatory networks. In the review, we have briefly summarized the latest processes in three-dimensional chromatin conformation, microscopic imaging, and bioinformatics, and we have presented the outlook and future directions for these three aspects. |
format | Online Article Text |
id | pubmed-9986247 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Research Network of Computational and Structural Biotechnology |
record_format | MEDLINE/PubMed |
spelling | pubmed-99862472023-03-07 Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology Zhu, Xiusheng Huang, Qitong Luo, Jing Kong, Dashuai Zhang, Yubo Comput Struct Biotechnol J Mini-Review Gene regulatory networks are now at the forefront of precision biology, which can help researchers better understand how genes and regulatory elements interact to control cellular gene expression, offering a more promising molecular mechanism in biological research. Interactions between the genes and regulatory elements involve different promoters, enhancers, transcription factors, silencers, insulators, and long-range regulatory elements, which occur at a ∼10 µm nucleus in a spatiotemporal manner. In this way, three-dimensional chromatin conformation and structural biology are critical for interpreting the biological effects and the gene regulatory networks. In the review, we have briefly summarized the latest processes in three-dimensional chromatin conformation, microscopic imaging, and bioinformatics, and we have presented the outlook and future directions for these three aspects. Research Network of Computational and Structural Biotechnology 2023-02-16 /pmc/articles/PMC9986247/ /pubmed/36890880 http://dx.doi.org/10.1016/j.csbj.2023.02.028 Text en © 2023 The Author(s) https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Mini-Review Zhu, Xiusheng Huang, Qitong Luo, Jing Kong, Dashuai Zhang, Yubo Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
title | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
title_full | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
title_fullStr | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
title_full_unstemmed | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
title_short | Mini-review: Gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
title_sort | mini-review: gene regulatory network benefits from three-dimensional chromatin conformation and structural biology |
topic | Mini-Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986247/ https://www.ncbi.nlm.nih.gov/pubmed/36890880 http://dx.doi.org/10.1016/j.csbj.2023.02.028 |
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