A homozygous PRKN-associated juvenile Parkinson's disease with pregnancy in China

BACKGROUND: Although Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by pa...

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Detalles Bibliográficos
Autores principales: Li, Hong-xing, Dong, Mei, Peng, Xiao-xiao, Liu, Yi-zhe, Wang, Han, Li, Chao, Du, Yi-yi, Zhang, Kai, Zong, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neurology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986302/
https://www.ncbi.nlm.nih.gov/pubmed/36891473
http://dx.doi.org/10.3389/fneur.2023.1103164
Descripción
Sumario:BACKGROUND: Although Parkinson's disease (PD) is the second most common neurodegenerative disorder, pregnancy in patients with PD is a relatively rare occurrence because the most common age of onset of PD is beyond the childbearing age, except in patients with Young-Onset PD (YOPD) caused by parkin RBR E3 ubiquitin protein ligase (PRKN) mutations. CASE: In this study, we report the case of a 30-year-old Chinese woman who was affected by PRKN-associated YOPD and was treated with levodopa/benserazide during pregnancy. She gave birth to a healthy baby boy with an Apgar score of 9 through an uncomplicated vaginal delivery. CONCLUSION: This case further suggests that levodopa/benserazide during pregnancy is safe in the treatment of PRKN-associated YOPD.

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