SARS-COV-2 viroporins activate the NLRP3-inflammasome by the mitochondrial permeability transition pore

BACKGROUND: Compared to healthy controls, severe COVID19 patients display increased levels of activated NLRP3-inflammasome (NLRP3-I) and interleukin (IL)-1β. SARS-CoV-2 encodes viroporin proteins E and Orf3a(2-E+2-3a) with homologs to SARS-CoV-1, 1-E+1-3a, which elevate NLRP3-I activation; by an unk...

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Detalles Bibliográficos
Autores principales: Guarnieri, Joseph W., Angelin, Alessia, Murdock, Deborah G., Schaefer, Patrick, Portluri, Prasanth, Lie, Timothy, Huang, Jessica, Wallace, Douglas C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986324/
https://www.ncbi.nlm.nih.gov/pubmed/36891303
http://dx.doi.org/10.3389/fimmu.2023.1064293

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