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The STC2–PAPP-A–IGFBP4–IGF1 axis and its associations to mortality and CVD in T2D

OBJECTIVE: Physiologically, pregnancy-associated plasma protein-A (PAPP-A) serves to liberate bound IGF1 by enzymatic cleavage of IGF-binding proteins (IGFBPs), IGFBP4 in particular. Clinically, PAPP-A has been linked to cardiovascular disease (CVD). Stanniocalcin-2 (STC2) is a natural inhibitor of...

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Detalles Bibliográficos
Autores principales:	Gude, Mette Faurholdt, Hjortebjerg, Rikke, Bjerre, Mette, Charles, Morten Haaning, Witte, Daniel R, Sandbæk, Annelli, Frystyk, Jan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Bioscientifica Ltd 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986395/ https://www.ncbi.nlm.nih.gov/pubmed/36607154 http://dx.doi.org/10.1530/EC-22-0451

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