A novel oral formulation of the melanocortin-1 receptor agonist PL8177 resolves inflammation in preclinical studies of inflammatory bowel disease and is gut restricted in rats, dogs, and humans

INTRODUCTION: PL8177 is a potent and selective agonist of the melanocortin 1 receptor (MC1R). PL8177 has shown efficacy in reversing intestinal inflammation in a cannulated rat ulcerative colitis model. To facilitate oral delivery, a novel, polymer-encapsulated formulation of PL8177 was developed. T...

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Detalles Bibliográficos
Autores principales: Dodd, John, Jordan, Robert, Makhlina, Marie, Barnett, Keith, Roffel, Ad, Spana, Carl, Obr, Alison, Dhingra, Priyanka, Kayne, Paul S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986545/
https://www.ncbi.nlm.nih.gov/pubmed/36891301
http://dx.doi.org/10.3389/fimmu.2023.1083333

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