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Functional association between telomeres, oxidation and mitochondria

Prior research has substantiated the vital role of telomeres in human fertility. Telomeres are prerequisites for maintaining the integrity of chromosomes by preventing the loss of genetic material following replication events. Little is known about the association between sperm telomere length and m...

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Autores principales: Moustakli, Efthalia, Zikopoulos, Athanasios, Sakaloglou, Prodromos, Bouba, Ioanna, Sofikitis, Nikolaos, Georgiou, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986632/
https://www.ncbi.nlm.nih.gov/pubmed/36890798
http://dx.doi.org/10.3389/frph.2023.1107215
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author Moustakli, Efthalia
Zikopoulos, Athanasios
Sakaloglou, Prodromos
Bouba, Ioanna
Sofikitis, Nikolaos
Georgiou, Ioannis
author_facet Moustakli, Efthalia
Zikopoulos, Athanasios
Sakaloglou, Prodromos
Bouba, Ioanna
Sofikitis, Nikolaos
Georgiou, Ioannis
author_sort Moustakli, Efthalia
collection PubMed
description Prior research has substantiated the vital role of telomeres in human fertility. Telomeres are prerequisites for maintaining the integrity of chromosomes by preventing the loss of genetic material following replication events. Little is known about the association between sperm telomere length and mitochondrial capacity involving its structure and functions. Mitochondria are structurally and functionally distinct organelles that are located on the spermatozoon's midpiece. Mitochondria produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS), which is necessary for sperm motility and generate reactive oxygen species (ROS). While a moderate concentration of ROS is critical for egg—sperm fusion, and fertilization, excessive ROS generation is primarily related to telomere shortening, sperm DNA fragmentation, and alterations in the methylation pattern leading to male infertility. This review aims to highlight the functional connection between mitochondria biogenesis and telomere length in male infertility, as mitochondrial lesions have a damaging impact on telomere length, leading both to telomere lengthening and reprogramming of mitochondrial biosynthesis. Furthermore, it aims to shed light on how both inositol and antioxidants can positively affect male fertility.
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spelling pubmed-99866322023-03-07 Functional association between telomeres, oxidation and mitochondria Moustakli, Efthalia Zikopoulos, Athanasios Sakaloglou, Prodromos Bouba, Ioanna Sofikitis, Nikolaos Georgiou, Ioannis Front Reprod Health Reproductive Health Prior research has substantiated the vital role of telomeres in human fertility. Telomeres are prerequisites for maintaining the integrity of chromosomes by preventing the loss of genetic material following replication events. Little is known about the association between sperm telomere length and mitochondrial capacity involving its structure and functions. Mitochondria are structurally and functionally distinct organelles that are located on the spermatozoon's midpiece. Mitochondria produce adenosine triphosphate (ATP) through oxidative phosphorylation (OXPHOS), which is necessary for sperm motility and generate reactive oxygen species (ROS). While a moderate concentration of ROS is critical for egg—sperm fusion, and fertilization, excessive ROS generation is primarily related to telomere shortening, sperm DNA fragmentation, and alterations in the methylation pattern leading to male infertility. This review aims to highlight the functional connection between mitochondria biogenesis and telomere length in male infertility, as mitochondrial lesions have a damaging impact on telomere length, leading both to telomere lengthening and reprogramming of mitochondrial biosynthesis. Furthermore, it aims to shed light on how both inositol and antioxidants can positively affect male fertility. Frontiers Media S.A. 2023-02-20 /pmc/articles/PMC9986632/ /pubmed/36890798 http://dx.doi.org/10.3389/frph.2023.1107215 Text en © 2023 Moustakli, Zikopoulos, Sakaloglou, Bouba, Sofikitis and Georgiou. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) (https://creativecommons.org/licenses/by/4.0/) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Reproductive Health
Moustakli, Efthalia
Zikopoulos, Athanasios
Sakaloglou, Prodromos
Bouba, Ioanna
Sofikitis, Nikolaos
Georgiou, Ioannis
Functional association between telomeres, oxidation and mitochondria
title Functional association between telomeres, oxidation and mitochondria
title_full Functional association between telomeres, oxidation and mitochondria
title_fullStr Functional association between telomeres, oxidation and mitochondria
title_full_unstemmed Functional association between telomeres, oxidation and mitochondria
title_short Functional association between telomeres, oxidation and mitochondria
title_sort functional association between telomeres, oxidation and mitochondria
topic Reproductive Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986632/
https://www.ncbi.nlm.nih.gov/pubmed/36890798
http://dx.doi.org/10.3389/frph.2023.1107215
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