Combining ASBT inhibitor and FGF15 treatments enhances therapeutic efficacy against cholangiopathy in female but not male Cyp2c70 KO mice

Therapeutic reduction of hydrophobic bile acids exposure is considered beneficial in cholestasis. The Cyp2c70 KO mice lack hydrophilic muricholic acids and have a human-like hydrophobic bile acid pool resulting in hepatobiliary injury. This study investigates if combining an apical sodium-dependent...

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Detalles Bibliográficos
Autores principales: Hasan, Mohammad Nazmul, Chen, Jianglei, Matye, David, Wang, Huaiwen, Luo, Wenyi, Gu, Lijie, Clayton, Yung Dai, Du, Yanhong, Li, Tiangang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986646/
https://www.ncbi.nlm.nih.gov/pubmed/36737039
http://dx.doi.org/10.1016/j.jlr.2023.100340

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986646/
https://www.ncbi.nlm.nih.gov/pubmed/36737039
http://dx.doi.org/10.1016/j.jlr.2023.100340

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