Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is the most common and aggressive form of acute leukemia, with a 5-year survival rate of just 24%. Over a third of all AML patients harbor activating mutations in kinases, such as the receptor tyrosine kinases FLT3 (receptor-type tyrosine-protein kinase FLT3) and KIT (ma...

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Detalles Bibliográficos
Autores principales: Murray, Heather C., Miller, Kasey, Brzozowski, Joshua S., Kahl, Richard G.S., Smith, Nathan D., Humphrey, Sean J., Dun, Matthew D., Verrills, Nicole M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9986649/
https://www.ncbi.nlm.nih.gov/pubmed/36682716
http://dx.doi.org/10.1016/j.mcpro.2023.100503

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